| 磷酸川芎嗪缓释透皮贴剂的制备及体外释放度测定 |
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| 引用本文： | 张蜀,林华庆,邓红. 磷酸川芎嗪缓释透皮贴剂的制备及体外释放度测定[J]. 药品评价, 2005, 2(4): 292-294 |
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| 作者姓名： | 张蜀 林华庆 邓红 |
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| 作者单位： | 广东药学院,广东,广州,510224 |
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| 摘 要： | 目的制备磷酸川芎嗪缓释透皮贴剂并优化其处方。方法通过正交实验,筛选缓释透皮贴剂的处方组成。结果采用聚丙烯酸树脂EUDRAGITE100为控释骨架和压敏胶材料,1.0%氮酮作为渗透促进剂制备胶粘剂骨架型经皮给药系统,药物从胶粘剂骨架/药物储库(压敏胶层)中恒速释放,体外释放度表明,贴剂的释放符合零级方程。结论所研制的磷酸川芎嗪缓释透皮贴剂具有理想的释药特性。
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| 关 键 词： | 磷酸川芎嗪 缓释透皮贴剂 投药 皮肤 |
| 文章编号： | 1672-2809（2005）04-0292-03 |
| 收稿时间： | 2005-05-13 |
| 修稿时间： | 2005-07-20 |
Preparation and in-vitro drug release of Ligustrazine Phosphate Sustained-release Patches |
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| ZHANG Shu,LIN Hua-Qing,DENG Hong. Preparation and in-vitro drug release of Ligustrazine Phosphate Sustained-release Patches[J]. Drug Evaluation, 2005, 2(4): 292-294 |
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| Authors: | ZHANG Shu LIN Hua-Qing DENG Hong |
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| Abstract: | Objective To optimize the formulation of Ligustrazine Phosphate Sustained- releasepatches. Methods The orthogonal design was used to screen the formulation of LigustrazinePhosphate Sustained- release patches. Results The optimal combination of the formulation isEUDRAGIT E100 as the pressure sensitive adhesive, AZONE is acted as the enhancer with thecontent 1.0%. The study of in vitro release confirmed that Ligustrazine Phosphate were released byzero order equation from the patches. Conclusion The prepared Ligustrazine Phosphate Sus-tained- release patches had an ideal release trait. |
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| Keywords: | Ligustrazine Phosphate Sustained- release patches administration cutaneous |
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