| RNA阻抑和基因沉默 |
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| 引用本文： | 张明,邵宁生. RNA阻抑和基因沉默[J]. 军事医学科学院院刊, 2002, 26(1): 61-65 |
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| 作者姓名： | 张明 邵宁生 |
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| 作者单位： | 军事医学科学院基础医学研究所,北京,100850 |
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| 摘 要： | 真核生物中 ,双链RNA(double_strandedRNA ,dsRNA)诱导产生特异性基因沉默 (genesilencing)的机制 ,被称为dsRNA介导的基因阻抑 (dsRNA_mediatedinterference ,RNAi) ,简称RNA阻抑。RNAi现在被认为是真核生物对病毒、转基因和转座因子 (transposableelements)的防御机制。本文回顾了RNAi的研究历程 ,并介绍了RNAi的机制假说及其在技术应用方面的进展
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| 关 键 词： | RNA 双链 RNA阻抑 基因沉默 |
| 文章编号： | 1000-5501(2002)01-0061-05 |
| 修稿时间： | 2001-10-15 |
RNA interference and gene silencing:a review |
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| ZHANG Ming,SHAO Ning_Sheng. RNA interference and gene silencing:a review[J]. Bulletin of the Academy of Military Medical Sciences, 2002, 26(1): 61-65 |
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| Authors: | ZHANG Ming SHAO Ning_Sheng |
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| Abstract: | The mechanism through which specific gene silencing is induced by double_stranded (dsRNA)in eukaryotes is called dsRNA mediated interference (RNAi). Now RNAi has been thought to be a defensive system against viruses, transgenes and transposable elements. Here we review the history of RNAi studies, describe a model for RNAi and introduce the development of the technique based on RNAi. |
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| Keywords: | RNA double_stranded RNA RNA interference gene silencing |
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