小儿哮喘患儿经普米克令舒联合孟鲁司特治疗前后肺功能及免疫学细胞因子水平变化研究

目的 分析小儿哮喘患儿经普米克令舒联合孟鲁司特治疗前后肺功能及免疫学细胞因子水平变化.方法 选取2018年3月至2019年3月本院儿科收治的哮喘患儿86例,中途退出4例,最终纳入82例.按照治疗方法将其分为联合组和单一组,各组41例.单一组在常规治疗基础上增加孟鲁司特钠咀嚼片,联合组在单一组基础上增加普米克令舒.比较治...

Changes of lung function and immunocytokine levels in children with asthma before and after treatment with Pulmicort-Respules combined with montelukast

Objective To analyze the changes of lung function and cytokine levels in children with asthma before and after treatment with Pulmicort-Respules combined with montelukast.Methods 86 children with asthma treated in our pediatric department from March 2018 to March 2019 were selected,4 patients withdrew midway and 82 patients were finally included.According to the treatment method,they were divided into a combination group and a single group,with 41 cases in each group.The single group were supplemented with montelukast sodium chewable tablets based on conventional treatment,and the combination group were supplemented with Pulmicort-Respules based on treatment of single group.Pulmonary function was compared between the two groups before and after treatment,including forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),forced expiratory volume in the first second/forced vital capacity(FEV1/FVC).Clinical efficacy,duration and times of asthma attacks before and after treatment were compared.IgE,TSLP levels and TLRs expression in peripheral blood were analyzed.Results After treatment,the levels of FVC,FEV1,FEV1/FVC in the combination group were higher than those in the single group.The decreasing of IgE and TSLP levels was more significant than that of the single group,and the difference was statistically significant(P<0.05).The changes of TLR2 and TLR4 expression in the combination group were more significant than those in the single group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the times of asthma attacks and duration between the two groups before treatment(P>0.05),while the times of asthma attacks and duration of attacks in the combination group were lower than those in the single group after treatment(P<0.05),and the total clinical effective rate of the combination group was higher than that of the single group(P<0.05).Conclusion Pulmicort-Respules combined with montelukast can improve the lung function and immune function of children with asthma and participate in the regulation of TLRs signaling pathway.The clinical effect is significant and it is worthy of promotion.