富马酸酮替芬分散片辅助治疗儿童喘息性支气管炎的疗效评价

目的 探讨富马酸酮替芬分散片辅助治疗喘息性支气管炎患儿的临床疗效.方法 选取喘息性支气管炎患儿102例,依照治疗方案不同分为研究组(n=56)和常规组(n=46).常规组采用白三烯受体拮抗剂治疗,研究组于常规组基础上采用富马酸酮替芬分散片治疗,统计比较两组临床疗效、治疗前、治疗4周后[血清巨噬细胞炎性蛋白-1ɑ(MIP...

Evaluation of the efficacy of ketotifen fumarate dispersible tablets in the adjuvant treatment of children with asthmatic bronchitis

Objective To investigate the clinical efficacy of ketotifen fumarate dispersible tablets in the adjuvant treatment of children with asthmatic bronchitis.Methods A total of 102 children with asthmatic bronchitis in our hospital were retrospectively selected and divided into study group(n=56)and routine group(n=46)according to different treatment schemes.The conventional group was treated with leukotriene receptor antagonists,and the research group was treated with ketotifen fumarate dispersible tablets based on the conventional group.The clinical efficacy,the levels of[serum macrophage inflammatory protein-1ɑ(MIP-1),eosinophil cationic protein(ECP)]before and after 4 weeks of treatment,the incidence of adverse reactions,and the recurrence rate were compared between the two groups.Results The total effective rate of treatment in the study group was 94.64%higher than that in the conventional group(78.26%)(P<0.05);after 4 weeks of treatment,serum ECP and MIP-1 levels in the study group were significantly lower than those in the conventional group(P<0.05);the incidence of adverse reactions in the study group was 7.14%compared with 4.35%in the conventional group(P>0.05);the relapse rate in the study group was 5.56%significantly lower than that in the conventional group 30.43%(P<0.05).Conclusion Ketotifen fumarate dispersible tablets in the adjuvant treatment of children with asthmatic bronchitis have a significant effect,which can effectively inhibit the body’s inflammatory response,reduce the recurrence rate,and have high safety.