参芪扶正注射液联合GP方案治疗非小细胞肺癌的近期疗效、免疫功能及远期生存研究

目的 研究参芪扶正注射液联合吉西他滨+顺铂(GP)方案治疗非小细胞肺癌(NSCLC)的近期疗效及对免疫功能、远期生存的影响.方法 回顾性选择2016年8月至2018年1月期间在解放军联勤保障部队第902医院诊断为晚期NSCLC并接受GP方案化疗的患者,根据化疗过程中是否加用参芪扶正注射液分为参芪扶正注射液联合GP方案治...

Short-term effect,immune function and long-term survival of Shenqifuzheng injection combined with GP regimen in the treatment of non-small cell lung cancer

Objective To study the short-term efficacy of Shenqifuzheng injection combined with GP regimen in the treatment of non-small cell lung cancer(NSCLC)and its effect on immune function and long-term survival.Methods From August 2016 to January 2018,the patients who were diagnosed as advanced NSCLC in People's Liberation Army Joint Logistics Support Unit No.902 Hospital and received GP regimen chemotherapy were divided into two groups according to whether Shenqifuzheng injection was added during the chemotherapy:the observation group treated with Shenqifuzheng injection combined with GP regimen and the control group treated with GP regimen alone.The differences of short-term efficacy,immune function,toxicity and long-term survival between the two groups were compared.Results After 2 courses of treatment,the total effective rate,disease control rate,peripheral blood CD3^+,CD4^+ and overall survival(OS)in the observation group was 43.90%,78.05%,(50.12±10.38)%,(32.38±5.84)%,which were all higher than those in the control group[24.07%,51.85%,(43.27±6.68)%,(27.33±5.56)%],the differences were statistically significant(P<0.05).The incidence of leukopenia in the observation group was 56.10%,the incidence of thrombocytopenia was 17.07%,and the incidence of gastrointestinal reactions was 68.29%,which were significantly lower than those in the control group(75.93%,37.04%,87.04%),and the differences were statistically significant(P<0.05).There was no significant difference in the CD8^+[(21.09±5.85)%vs.(20.94±7.47)%]and the incidence of liver damage(21.95%vs.33.33%)in the peripheral blood of the two groups(P>0.05).Conclusion Shenqifuzheng injection combined with GP can improve the short-term efficacy and long-term survival of NSCLC,and also reduce the immunosuppression and toxicity effects caused by chemotherapy.