中医药干预铁死亡机制的研究进展

铁死亡是近年来发现的一种全新的细胞死亡方式,与正常细胞凋亡和坏死不同,铁死亡具有铁离子的依赖性。铁死亡的发生与细胞内脂质活性氧(reactive oxygen species,ROS)的平衡失调息息相关,其通过介导脂质过氧化(lipid peroxidation,LPO),调节谷胱甘肽(glutathione,GSH)和谷胱甘肽过氧化物酶4(glutathione peroxidase 4,GPX4),依赖细胞内铁、ROS和氧化还原稳态失衡,根据Fe-ROS或者GSH-GPX4-ROS信号通路介导细胞死亡。中药具有多靶点、多通路的优势,干预铁死亡具有一定的疗效和价值,本文总结了铁死亡的相关机制,汇总了近年来中医药领域通过GSH-GPX4-ROS通路介导铁死亡的实验研究成果,以期为疾病铁死亡的靶点治疗提供参考。

Research Progress of Chinese Medicine on the Mechanism of Ferroptosis

Ferroptosis is a new way of cell death discovered in recent years,which is different from normal cell apoptosis and necrosis.Ferroptosis is iron dependent.Ferroptosis is closely related to the imbalance of intracellular reactive oxygen species(ROS),which mediates lipid peroxidation(LPO)and regulates glutathione(GSH)and glutathione peroxidase 4(GPX4),relies on the imbalance of intracellular iron,ROS and redox homeostasis,and mediates cell death according to the Fe-ROS or GSH-GPX4-ROS signaling pathway.Traditional Chinese medicine has the advantages of multi-target and multi-channel,intervention of ferroptosis has certain curative effect and value.This paper summarized the related mechanisms of ferroptosis,summarized the experimental research results of ferroptosis mediated by GSH-GPX4-ROS pathway in the field of traditional Chinese medicine in recent years,in order to provide reference for the target treatment of ferroptosis.