| 蛋白质组学分析在年龄相关性黄斑变性研究中的应用 |
| |
| 引用本文： | 杨帆(综述),孙晓东(审校). 蛋白质组学分析在年龄相关性黄斑变性研究中的应用[J]. 中华实验眼科杂志, 2021, 0(1): 72-77 |
| |
| 作者姓名： | 杨帆(综述) 孙晓东(审校) |
| |
| 作者单位： | 上海市第一人民医院眼科 |
| |
| 基金项目： | 国家重点研发计划资助项目(2016YFC0904800);国家科技重大专项资助项目(2017ZX09304010);国家自然科学基金重点项目(81425006)。 |
| |
| 摘 要： | 年龄相关性黄斑变性是老年人群中主要的不可逆致盲眼病，其主要致病因素包括年龄增长、遗传变异和生活方式等，但具体致病机制尚未完全阐明。蛋白质组学技术作为近年来新兴的研究手段已经逐步应用于眼科领域。目前已经有大量研究对该疾病患者的血液、泪液、房水、玻璃体液、视网膜和脉络膜、玻璃疣以及视网膜色素上皮细胞标本进行了蛋白质组学分析...
|
| 关 键 词： | 蛋白质组学 年龄相关性黄斑变性 生物标志物 |
Application of proteomics in age-related macular degeneration |
| |
| Affiliation: | (Department of Ophthalmology,Shanghai General Hospital,National Clinical Research Center for Eye Diseases,Shanghai Key Laboratory of Ocular Fundus Diseases,Shanghai Engineering Center for Visual Science and Photomedicine,Shanghai Engineering Center for Precise Diagnosis and Treatment of Eye Disease,Shanghai 200080,China) |
| |
| Abstract: | Age-related macular degeneration(AMD)is the mainirreversible blinding eye disease in the elderly.Its main pathogenic factors include age,genetic variation and lifestyle,but the specific pathogenesis has not been fully elucidated.As an emerging research method,proteomics technology has been gradually applied in the field of ophthalmology in recent years.A large number of studies about proteomic analysis of blood,tears,aqueous humor,vitreous humor,retina and choroid,drusen and RPE cell samples from AMD patients have been carried out to screen AMD biomarkers and explore the mechanism of AMD.These results can not only help us to make a more accurate diagnosis of AMD,but also play a guiding role in the selection of treatment targets and prognosis. |
| |
| Keywords: | Proteomics Age-related macular degeneration Biomarkers |
| 本文献已被 维普 等数据库收录！ |
|
