| AMPK信号通路及其在感染性疾病中的研究进展 |
| |
| 引用本文： | 颜明智,赵军,刘辉,毕晓娟,吕国栋.AMPK信号通路及其在感染性疾病中的研究进展[J].热带病与寄生虫学,2021,19(1):47-51. |
| |
| 作者姓名： | 颜明智 赵军 刘辉 毕晓娟 吕国栋 |
| |
| 作者单位： | 1.新疆医科大学第一附属医院临床医学研究院省部共建中亚高发病成因与防治国家重点实验室,新疆乌鲁木齐830054;2.新疆医科大学药学院;3.新疆医科大学第一附属医院药学部临床药学科 |
| |
| 基金项目： | 国家自然科学基金项目(82060373,81760369);省部共建中亚高发病成因与防治国家重点实验室开放课题(SKL-HIDCA-2017-Y1);中国博士后科学基金面上项目(2019M653802)。 |
| |
| 摘 要： | 腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)是一种AMP依赖性的蛋白激酶,负责调节细胞能量的合成与分解,是细胞生长、繁殖和自噬的关键调节剂。AMPK及其信号通路在病毒、细菌和寄生虫等感染中发挥了重要作用,有望成为一种药物新靶点。本文将对近年来AMPK信号通路在感染性疾病中的研究展开综述。
|
| 关 键 词： | 腺苷酸活化蛋白激酶信号通路 能量代谢 感染性疾病 病原体 药物靶点 |
AMPK signaling pathway and its research progress in infectious diseases |
| |
| YAN Ming-zhi,ZHAO Jun,LIU Hui,BI Xiao-juan,Lü Guo-dong.AMPK signaling pathway and its research progress in infectious diseases[J].Journal of Tropical Diseases and Parasitology,2021,19(1):47-51. |
| |
| Authors: | YAN Ming-zhi ZHAO Jun LIU Hui BI Xiao-juan LÜ Guo-dong |
| |
| Institution: | 1 State Key Laboratory of Pathogenesis Prevention and Treatment of Central Asian High Incidence Diseases Clinical Medical Research Institute The First Affiliated Hospital of Xinjiang Medical University ,Urumqi 830054 ,Xinjiang Uygur Autonomous Region ,China;2 College of Pharmacy Xinjiang Medical University;3 Department of Clinical Pharmacy The First Affiliated Hospital of Xinjiang Medical University |
| |
| Abstract: | AMP-activated protein kinase(AMPK),an AMP-dependent protein kinase responsible for regulating the synthesis and catabolism of cellular energy,is a key regulator for cell growth,reproduction and autophagy.AMPK and its signaling pathway play an important role in viral,bacterial and parasitic infections and are expected to be a new drug target.In this paper,we reviewed the recent research on AMPK signaling pathway in infectious diseases. |
| |
| Keywords: | AMPK signaling pathway Energy metabolism Infectious diseases Pathogens Drug targets |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《热带病与寄生虫学》浏览原始摘要信息 |
| 点击此处可从《热带病与寄生虫学》下载免费的PDF全文 |
