心肺复苏成功后亚低温治疗临床效果研究及氧化应激因子水平变化

目的探究心肺复苏(CPR)成功后亚低温治疗临床效果及氧化应激因子水平变化。方法选择2017年10月至2019年6月新疆医科大学第六附属医院收治的106例心肺复苏患者为研究对象,两组患者心搏骤停(SCA)发生时立即进行CPR治疗,观察组在此基础上进行阶段式亚低温治疗。比较两组患者治疗后各时间段临床指标、血清氧化应激因子水平和并发症情况。结果治疗后3 d,治疗后10d和治疗后28 d,观察组GCS评分均明显高于对照组,差异具有统计学意义(均P=0.000)。治疗后10 d和治疗后28 d,观察组SOFA评分均明显低于对照组,差异具有统计学意义(均P=0.000)。心肺复苏成功后和治疗后1 d,两组上述血清总抗氧化状态,丙二醛和超氧化物歧化酶水平均明显下降,差异具有统计学意义(P<0.05);其中观察组各指标变化均较对照组更为明显,差异具有统计学意义(P<0.05)。对照组和观察组并发症总发生率分别为26.42%和13.21%,差异具有统计学意义(P<0.05)。结论心肺复苏成功后亚低温治疗能够明显降低患者昏迷和器官衰竭发生,降低血清氧化应激因子水平,同时降低并发症发生率,值得临床推广和应用。

Study on the clinical effect of mild hypothermia after successful cardio-pulmonary resuscitation and changes in oxidative stress factor levels

Objective To investigate the clinical effects of mild hypothermia and the changes of oxidative stress factors af-ter cardiopulmonary resuscitation.Methods A total of 106 patients with cardiopulmonary resuscitation admitted to theSixth Affiliated Hospital of Xinjiang Medical University from October 2017 to June 2019 were selected as the researchsubjects.Two groups of patients were immediately treated with CPR when SCA occurred.treatment.Compare the clinicalindexes,serum oxidative stress factor levels and complications of the two groups of patients at various time periods aftertreatment.Results 3 days after treatment,10 days after treatment,and 28 days after treatment,the GCS scores in the ob-servation group were significantly higher than those in the control group,and the differences were statistically significant(all P=0.000).10 days after treatment and 28 days after treatment,the SOFA scores in the observation group were signifi-cantly lower than those in the control group,and the difference was statistically significant(both P=0.000).After cardio-pulmonary resuscitation and l day after trealment,the serum total antioxidant status,MDA,and superoxide dismutaselevels in the two groups significantly decreased,and the differences were statistically significant(P<0.05);the indicatorsin the observation group changed All were more obvious than the control group,and the difference was statistically signifi-cant(P<0.05).The total incidence of complications in the control group and observation group was 26.42%and 13.21%.respectively,and the difference was statistically significant(P<0.05).Conclusion After the cardiopulmonary resuscita-tion,mild hypothermia can significantly reduce the incidence of coma and organ failure,reduce the level of serum oxida-tive stress factors,and reduce the incidence of complications.It is worthy of clinical promotion and application.