浅谈维库溴铵与阿曲库铵在手术患者中应用效果

目的：探讨维库溴铵和阿曲库铵非去极化肌松药不同阻滞深度对择期手术患者的影响。方法选取2011年5月-2013年5月间于本院行择期手术治疗的患者54例，按其手术治疗顺序进行编号并随机分为对照组（27例）和观察组（27例），对照组患者麻醉应用维库溴铵肌松药，观察组患者麻醉应用阿曲库铵肌松药，术后均进行新斯的明拮抗。结果观察组患者肌松药用量明显高于对照组，组间差异具有统计学意义（P〈0.05）；两组患者新斯的明用量、停药-拮抗时间、TR值至0.75时间、不同阻滞程度比例等指标差异无统计学意义，患者拮抗前、后血压、心率差异无统计学意义（P〉0.05）。结论维库溴铵和阿曲库铵肌松效果类似，新斯的明术后拮抗肌松效果优，安全性更高。

Intro duction of vecuronium bromide and atracurium in the application of surgery

Objective To investigate the impact of the different block depth of vecuronium bromide and atracurium （non depolarizing muscle relaxant） on undergoing elective surgery patients. Methods To select 54 cases of patients accepting selective surgical treatment in our hospital from May 2011 to May 2013. To divede patients into control group （27 cases） and observation group （27 cases） according to their order number of accepting surgical treatmentdi, and the anesthesia of control group patients was vecuronium bromide, the anesthesia of observation group of patients was atracurium, neostigmine antagonism was used after operation. Results The dose of muscle relaxant of the observation group of patients was significantly higher than that of the control group, the differences between groups was with statistical significance （P〈0.05）;The differences of indicators of two groups of patients were not obvious, such as neostigmine dosage, drug withdrawal-antagonism time, TR value to 0.75 time, different degree of blocking ratio index, and the blood pressure, heart rate in patients before and after antagonism, they were not statistically significant （P〉0.05）. Conclusion The muscle relaxant effect of vecuronium bromide and atracurium is similar, the postoperative antagonist of muscle relaxant is good with higher safety.