Haemodynamic effects of rocuronium during fentanyl anaesthesia: comparison with vecuronium

Haemodynamic variables were measured following administration of rocuronium 0.6 mg· kg^?1 or vecuronium 0.08 mg · kg^?1 (approximately equivalent to 2 × ED₉₅ doses) in patients anaesthetized with fentanyl 50 μg· kg^?1 and scheduled to undergo elective coronary artery bypass grafting. There were increases in stroke volume index (+15%) and cardiac index (+11%), and a decrease in pulmonary capillary wedge pressure (?25%) following administration of rocuronium (P < 0.05). The changes in heart rate (+7%), mean arterial pressure (?5%), systemic vascular resistance (?12%) and other measured or derived indices were insignificant. In comparison the administration of vecuronium was associated with decreases in heart rate (?7%), mean pulmonary artery pressure (?17%), central venous pressure (?15%) and the rate-pressure product (?9%) (P < 0.05). The changes in mean arterial pressure (?7%), cardiac index (?6%) and systemic vascular resistance (?8%) following vecuronium were insignificant. There were no differences in any of the variables between rocuronium and vecuronium. The absolute values of all variables were, however, within acceptable clinical limits. There was no evidence of histamine release in any patient. The present study shows that rocuronium 0.6 mg · kg^?1 is associated with changes of only small magnitude in haemodynamic variables.