Studies on controlled release of indomethacin from PVA hydrogel |
| |
Authors: | Chi Ho Lee Kyoung Jin Lee Ae Jin Park Young Hee Shin |
| |
Institution: | 1. College of Pharmacy, Pusan National University, 609-735, Pusan, Korea 2. College of Pharmacy, Kyoungsung University, 608-746, Pusan, Korea
|
| |
Abstract: | The polyvinyl alcohol (PVA) hydrogel containing 1-methyl-2-pyrrolidinone (MP) and sorbitol was preapred by the freeze and thaw method. The release rate of indomethacin from PVA hydrogel was used as a criterion for deciding the optimum formula of hydrogel using the computer optimization technique. The hydrogel of optimum formula was composed of PVA (10 w/v%), MP (0 w/v%), and sorbitol (40 w/v%) and the release rate of indomethacin was 1.981 μg/ml·min1/2. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|