Synthesis of 7-[p-(methylthio)benzoyl]-5-benzofuranacetic acid |
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| Authors: | Hong Dae Choi Dek Hyun Geum Yong Sil Kowak Byeng Wha Son |
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| Institution: | 1. Department of Chemistry, Dongeui University, Gaya-dong, Pusanjin-ku, 614-714, Pusan, Korea
2. Department of Chemistry, National Fisheries University of Pusan, 608-023, Pusan, Korea
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| Abstract: | A new method was described for the preparation of 7-p-(methylthio)benzoyl]-5-benzofuranacetic acid6, which is an analgesic agent. Methyl 5-(2,3-di-hydrobenzofuran)acetate3 was obtained by Friedel-Crafts reaction of 2,3-dihydrobenzofuran with methyl α-chloro-α-(methylthio)actate1 and desulfurization of2. Tifurac6 was synthesized from acylation of 3 with p-(methylthio)benzoyl chloride followed by bromination of4, dehydrohalogenation, and hydrolysis of5. |
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