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Effects of an anti-interleuktn-6 (IL-6) murine monoclonal antibody in a patient with acute monoblastic leukemia |
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| Authors: | R Bataille X G Zhang J Wijdenes J-F Schved B Klein |
| Institution: | 1. Laboratoire d’Hématologie et Laboratoire d’Oncogénèse Imrnunohématologique, Institut de Biologie des Hêpitaux de Nantes, 9 quai Moncousu, 44035, Nantes Cédex, France 2. C. R. T. S. Besan?on, Avenue Fleming, 25030, Besan?on, France 3. Laboratoire d’Hématologie et Immunologie, Hêpital Gaston Doumergue, 5 rue Hoche, B. P. 26, 30006, Nimes Cedex, France |
| Abstract: | Because IL-6 has been involved in the pathogenesis of acute monoblastic leukemia, we investigated thein vitro anti-proliferative effect and thein vivo anti-tumoral effect of an anti-IL-6 murine monoclonal antibody (mAb) in a patient with MSB type acute leukemia. In the current study, we clearly show the IL-6 dependence of monoblastic cell viability and proliferationin vitro in short-term cultures of malignant cells and the clinical activity of the anti-IL-6 murine mAb. The complete neutralization of IL-6in vivo was associated with a transient but complete disappearance of malignant monoblastic cells in the peripheral blood, with improvement or even normalization of several other biological parameters of disease activity, No immunization against the anti-IL-6 murine mAb was observed. |
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