29例原发腮腺非霍奇金淋巴瘤的治疗结果分析

目的探讨腮腺非霍奇金淋巴瘤的临床特点、治疗及预后.方法回顾性分析29例原发性腮腺淋巴瘤.用Kaplan-Meier法计算其生存率,用Logrank法行差异显著性检验及生存因素分析(性别、年龄、分期、是否化疗、化疗疗程、是否放射治疗、腮腺区照射剂量).结果全组5、10年总生存率分别为73.3%、51.0%,早期(ⅠE+ⅡE)病变的预后明显好于晚期(ⅢE+ⅣE)病变(χ2=15.75, P＜0.01),黏膜相关淋巴组织淋巴瘤(MALTL)好于弥漫性大B细胞淋巴瘤(DLBCL)(χ2=5.16,P＜0.05).结论腮腺淋巴瘤预后较好,以肿块切除术或浅叶切除术为主的手术仅作为明确诊断的工具;对于MALTL和早期的滤泡性淋巴瘤(FL)可单纯放射治疗,早期DLBCL需行放射治疗+化疗的综合治疗,晚期DLBCL以化疗为主.

Treatment of primary parotid non-Hodgkin''''s lymphoma: an analysis of 29 patients

Objective To analyze the clinical characteristics, treatment and prognosis of primary parotid non-Hodgkin's lymphoma. Methods From March 1988 to February 2001, twenty-nine patients with primary parotid non-Hodgkin' s lymphoma treated in our hospital were retrospectively analyzed. The data were analyzed according to the following factors: sex, age, stage, pathologic classification, chemotherapy given or not, cycles of chemotherapy, radiotherapy given or not, and the dose at the parotid. Kaplan-Meier method and Log-rank method were used in the statistic analysis. Results The overall 5-year and 10-year survival rates were 73. 3% and 51.0% . Stage and pathologic classification were prognostic factors in our statistic analysis. The 5-year survival rates were 81.6% and 25.0% for early stage ( I E + IIE) and advanced stage ( III E + IVE) patients, with the difference significant ( P < 0.01) . The 5-year survival rate for patients with the pathologic classification of mucosa associated lymphoid tissue (MALT) was 100% as compared to 42.2% for patients with diffused large B cell lymphoma, with the difference also significant ( P < 0.05). Conclusions The prognosis of primary parotid non-Hodgkin s lymphoma is satisfactory. Surgery should only be used as a diagnostic method. Radiotherapy should be the first choice for patients with MALT lymphoma and stage I E and II E follicular lymphoma, but comprehensive treatment including chemotherapy is necessary to the diffuse large B cell lymphoma. .