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Association between Restriction Fragment Length Polymorphism of the Human Cytochrome P450IIE1 Gene and Susceptibility to Lung Cancer |
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| Authors: | Fumiyuki Uematsu Hideaki Kikuchi Masakichi Motomiya Tatsuya Abe Ikuko Sagami Tetsuo Ohmachi Akira Wakui Ryunosuke Kanamaru Minro Watanabe |
| Affiliation: | Department of Cancer Chemotherapy and Prevention, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980;Department of Internal Medicine, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980;Department of Clinical Cancer Chemotherapy, The Research Institute for Tuberculosis and Cancer, Tohoku University, 4–1 Seiryomachi, Aoba–ku, Sendai 980 |
| Abstract: | Cytochrome P450IIE1 (P450IIE1) is involved in metabolic activation of carcinogenic nitrosamines, aniline and benzene. We detected a restriction fragment length polymorphism of the human P450IIE1 gene with the restriction endonuclease Oral. The population was thus divided into three genotypes, namely, heterozygotes (CD) and two forms of homozygotes (CC and DD). The distribution of these genotypes among lung cancer patients differed front that among controls with statistical significance of P< 0.05 (x |
| Keywords: | Cytochrome P450IIE1 Nitrosamine metabolism Lung cancer Restriction fragment length polymorphism |