肺癌患者化疗前后血清IL-2,SIL-2R检测的临床意义

目的 :分析了 36例肺癌患者化疗前后血清中IL - 2和SIL - 2R水平的变化。方法 :采用放射免疫分析法测定患者血清中IL - 2和使用ELISA法测定SIL - 2R含量 ,并与 35名正常健康人作比较。结果 :化疗前IL- 2活性明显低于正常人 ,SIL - 2R水平明显高于正常人 (P <0 .0 1 ) ,化疗后 6个月复发者IL - 2 /SIL - 2R水平持续异常 ,未复发者IL - 2 /SIL - 2R水平恢复正常。结论 :观察肺癌患者免疫功能的变化与患者的病情和预后密切相关。

Clinical Significance of Measurement of Changes of Serum IL-2, SIL-2R Levels After Chemotherapy in Patients with Lung Carcinoma

Objective To study the changes of serum IL-2 and SIL-2R levels after chemotherapy in 36 patients with lung carcinoma. Methods Serum IL-2 (with RIA) and SIL-2R (with ELISA) levels were measured in 36 patients with lung carcinoma both before and after chemotherapy as well as in 35 controls. Results Before chemotherapy, in the patients the serum IL-2 levels were significantly lower and serum SIL-2R levels were significantly higher than those in the controls ( P <0.01). Six months after chemotherapy, those patients without recurrence ( n=20 ) had their IL-2 and SIL-2R levels returned to normal but in those with recurrences ( n=12 ) the levels were about the same as before. Conclusion Cytokines IL-2 and SIL-2R levels changes could reflect the immunostatus of the patient as well as the progress of disease and could be of prognostic value.