Inhibition of cyclooxygenase-independent platelet aggregation by sodium salicylate |
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Authors: | F. Violi C. Alessandri D. Pratic A. Guzzo A. Ghiselli F. Balsano |
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Affiliation: | Institute of Clinical Medicine I, University of Rome “La Sapienza”, Policlinico Umberto I, 00161, Rome, Italy |
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Abstract: | The effect of acetylsalicylic acid (ASA) on platelet aggregation (PA) and thromboxane A2 (TxA2) formation was investigated in vitro and ex vivo after 1 g or 300 mg ASA administration to healthy subjects. 50–100 μM ASA inhibited PA by single aggregating agent such as platelet aggregating factor (PAF) or epinephrine and reduced to 5% of control platelet TxB2 formation, but did not influence PA by epinephrine plus PAF. The latter was inhibited by increasing ASA concentration. In samples incubated with 100 μM ASA and stimulated with epinephrine plus PAF, PA could be inhibited by the addition of 100–300 μM sodium salicylate. After 300 mg-1 g ASA administration to healthy subjects, the inhibition of PA by epinephrine plus PAF was more marked by highest doses of ASA. This study suggests that aspirin inhibits PA with a cy clooxygenase-independent mechanism; this effect is mediated, at least in vitro, by salicylic acid. |
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Keywords: | Author Keywords: acetylsalicylic acid platelet aggregation thromboxane |
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