急性脑梗死患者血浆CD62p水平动态变化的研究

目的：通过研究急性脑梗死患者血浆CD62p 水平的动态变化，探讨CD62p 在脑梗死中的作用及其水平变化与脑梗死的病情程度和预后,MPV,PLT和PDW的关系。方法：用ELISA法测定60例脑梗死患者发病第48 h，第6～8 d及第15 d血浆CD62p水平，同时进行神经功能缺损评分评定病情程度，并测定MPV,PLT和PDW。同期测定30例健康对照者血浆CD62p 水平。结果：脑梗死患者血浆CD62p水平较对照组明显增高，差异有统计学意义（P<0.01）；第48 h血浆CD62p水平较其它两时期高，差异有统计学意义（P<0.01）；中、重度神经功能缺损者的血浆CD62p水平增高程度较轻度神经功能缺损者高，差异有统计学意义（P<0.01）；血浆CD62p 水平与SSS,MPV和PDW成正相关（r=0.61,0.51,0.47, P<0.01）,与PLT成负相关（r=-0.32, P<0.01）。结论：CD62p 可能参与了脑梗死并发挥重要作用，其水平变化与SSS,MPV,PDW和 PLT有关。

Changes of plasma CD62p levels in patients with acute cerebral infarction

OBJECTIVE: To explore the function of CD62p in cerebral infarction and the relation between the changes of its level and the severity and recovery of cerebral infarction, MPV, PDW and PLT by studying the changes of the levels of plasma CD62p in patients with acute cerebral infarction. METHODS: The levels of plasma CD62p were measured by ELISA in 60 patients at 48 hours, 6 - 8 days and 15 days after ischemia, and at the same time, we evaluated neurological function deficiency score and measured MPV, PDW and PLT. The levels of 30 healthy persons mating cerebral infarction group in both sex and ages were measured. RESULTS: The levels of plasma CD62p in the patients with acute cerebral infarction were obviously higher than the levels of the healthy controls (P < 0.001). The levels of plasma CD62 p in CI group at 48 hours postischemia were higher than the levels at 6 - 8 days and at 15 days with obvious difference (P <0.01). The levels of plasma CD62p in the medium and the severe SSS patients were higher than the levels of the lights (P <0.001). The levels of plasma CD62p were positively correlated with SSS, MPV and PDW (r = 0.61, 0.51, 0.47, P < 0.01), and negatively correlated with PLT (r = -0.32, P < 0.01). CONCLUSION: CD62p may participate in acute cerebral infarction and play a crucial role, and the change of its levels correlates with SSS, MPV, PDW and Plt.