尼莫地平,非洛地平和维拉帕米对离体人血管作用(英文)

目的:观察尼莫地平(Nim),非洛地平(Fel)是否有不同的作用模式.方法:比较尼莫地平(Nim),非洛地平(Fel)对去甲肾上腺素(NE)和氯化钙(CaCl_2)引起的人动脉收缩的不同作用,并且与维拉帕米(Ver)的作用相比较.结果:Nim,Fel和Ver对无Ca~(2 )高K~ 去极化时CaCl_2所致离体人血管收缩的拮抗作用比其对NE引起收缩拮抗作用强。在CaCl_2引起收缩时,Nim,Fel和Ver拮抗作用pD_2~′在子宫动脉分别为7.50,7.42,6.35;在肠系膜动脉分别为7.38,7.65和7.20;在肾动脉分别为7.87,9.10和7.32,Ver可抑制NE所致的两种收缩成分,Nim或Fel仅抑制外Ca~(2 )内流引起收缩.结论:Fel对肾血管有选择作用.

Effects of nimodipine, f elodipine, and verapamil on isolated human arteries

AIM:To evaluate whether there might be some difference in the action modes of nim-odipine (Nim) and felodipine (Fel). METHODS: Compare the inhibitory effects of Nim and Fel with that of verapamil (Ver) as a representative of phenylalklamine on nore-pinephrine (NE)- and CaCl2-evoked contractions of human arteries. RESULTS: In Ca2 -free and high K depolarized solution, inhibitory effects of Nim,Fel, and Ver were more potent on CaCl2-induced contractions on isolated human arteries than those on NE-induced contractions. In CaCl2-induced contraction, the pD2 values for Nim,Fel, and Ver were 7. 5, 7. 42, 6. 35 on uterine arteries; 7. 38, 7. 65, 7. 20 on mesenteric arteries and 7.87, 9. 10, 7. 32 on renal arteries , respectively. Ver inhibited 2 components of NE-e-voked contraction, while Nim and Fel only inhibited extracellular Ca2 -dependent contractions. CONCLUSION: The result indicates that Fel has a selective action on human renal arteries.