| 急性冠状动脉综合征患者血清中趋化因子的检测及意义 |
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| 引用本文： | 车少敏,王燕妮,马爱群. 急性冠状动脉综合征患者血清中趋化因子的检测及意义[J]. 临床心血管病杂志, 2003, 19(2): 87-89 |
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| 作者姓名： | 车少敏 王燕妮 马爱群 |
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| 作者单位： | 西安交通大学心血管内科,西安,710061 |
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| 摘 要： | 目的 :观察急性冠状动脉综合征 (ACS)发病时炎性趋化因子的作用 ,探讨ACS发病机制。方法 :选取ACS患者 80例 ,其中急性心肌梗死 (AMI) 4 0例 ,不稳定型心绞痛 (UAP) 4 0例。ACS患者经治疗 4个月后进行随访。同时选取正常对照 4 0例。采用酶联免疫法测定上述病例和对照者血清中的巨噬细胞趋化蛋白 1(MCP 1)、白细胞介素 8(IL 8)水平 ,并进行统计学分析。结果 :AMI组、UAP组MCP 1显著高于对照组 ,并在随访时明显降低 ,而IL 8水平无明显差异。结论 :外周血中MCP 1水平可以作为诊断和预测ACS发生的敏感指标 ,并可以反映病情的稳定情况 ,在临床工作中有一定的应用价值
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| 关 键 词： | 急性冠状动脉综合征 趋化因子 巨噬细胞 白细胞介素8 |
| 文章编号： | 1001-1439(2002)12-0087-03 |
| 修稿时间： | 2002-07-10 |
Serum levels of chemoattractants MCP-1, IL-8 in patients with acute coronary syndrome and their clinical significance |
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| CHE Shaomin WANG Yanni MA Aiqun. Serum levels of chemoattractants MCP-1, IL-8 in patients with acute coronary syndrome and their clinical significance[J]. Journal of Clinical Cardiology, 2003, 19(2): 87-89 |
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| Authors: | CHE Shaomin WANG Yanni MA Aiqun |
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| Abstract: | Objective:To study the serum levels of certain inflammatory chemoattractants and its significance in acute coronary syndrome (ACS).Methods:The study population included 40 patients with acute myocardial infarction (AMI) and 40 patients with unstable angine pectons (UAP). 60 patients accepted a follow up 4 months. At the same time, we selected 40 controls from people who attended a routine health check.Serum levels of MCP 1?IL 8 were measured by means of ELISA.Results:Serum levels of MCP 1 were significantly higher in the ACS group than those in the control group, and became significantly lower at the fourth month after treatment, while the lerel of IL 8 showed no significant difference after freatment. Conclusion:Serum levels of MCP 1 may have certain diagnostic value for ACS, and can be a useful maker reflecting the an unstable stable of the disease. |
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| Keywords: | Acute coronary syndrome Chemotactic factor macrophage Interleukin 8 |
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