NT-proBNP和hs-CRP水平与急性冠脉综合征严重程度及近期预后的相关性研究

目的探讨超敏C反应蛋白(hs-CRP)及血浆氨基末端脑钠肽前体(NT-proBNP)与急性冠脉综合征(ACS)严重程度及近期预后的相关性。方法选取经冠状动脉造影(CAG)明确诊断为ACS患者86例,分为稳定型心绞痛(SA)组32例、不稳定型心绞痛(UA)组24例、急性心肌梗死(AMI)组30例,另外选取健康体检者30例作为对照组。入院即刻抽取患者静脉血进行hs-CRP及NT-proBNP的检测,然后进行综合治疗,观察并比较各组住院期间不良预后发生率。结果与对照组比较,SA组、UA组及AMI组血清hs-CRP、NT-proBNP水平显著升高;AMI组血清hs-CRP、NT-proBNP水平较UA组高,AMI组、UA组血清hs-CRP、NT-proBNP水平较SA组高。与SA组比较,UA组及AMI组AMI、左心功能不全及恶性心律失常发生率明显增高,与UA组比较,AMI组AMI、左心功能不全发生率明显增高;hs-CRP、NT-proBNP水平与ACS患者的严重程度及AMI、左心功能不全及恶性心律失常发生率呈正相关。结论 ACS患者的hs-CRP、NT-proBNP水平显著升高,且与冠脉病变的严重程度及患者短期不良并发症的发生率正相关;hs-CRP及NT-proBNP水平可以作为评价冠状动脉硬化程度的检验指标,并且可以作为ACS的病情预测及疗效评定的指标。

Study on the correlation of hs-CRP and NT-proBNP with severity degree and short-term prognosis of acute coronary syndrome

Objective It is to investigate the relationships between the correlation of hypersensitive C-reaction protein(hs-CRP) and N-terminal pro-brain natriuretic peptide(NT-proBNP)with severity degree and short-term prognosis of acute coronary syndrome(ACS).Methods 86 patients with acute coronary syndrome diagnosed definitely by coronary angiography(CAG) were grouped into stable angina group(SA group,n=32),unstable angina group(UA group,n=24),acute myocardial infarction group(AMI group,n=30),and 30 healthy volunteers were selected as control group.Vein blood of the patients was gotten to determine the levels of hs-CRP,NT-proBNP at hospitalization,then them were treated with comprehensive therapy,and the occurrence rate of bad prognosis in every group was observed and compared.Results Compared with control group,the levels of serum hs-CRP,NT-proBNP were increased significantly in the SA,UA and AMI groups,the levels of AMI group was higher than that of UA group.Compared with that of SA group,the levels of AMI group and UA group were higher.The incidence of AMI,left heart dysfunction and malignant ventricular arrhythmia were increased significantly in UA group and AMI group compared with that in SA group.The occurrence rates of AMI and left heart dysfunction in AMI group were higher than that in UA group.The levels of hs-CRP,NT-proBNP were positively related with the severity degree and the incidence of AMI,left heart dysfunction and malignant ventricular arrhythmia.Conclusion The levels of hs-CRP,NT-proBNP are increased remarkably in the ACS patients,which is positively related with severity degree of coronary artery disease and the incidence of short-term adverse cardiac events.The levels of hs-CRP and NT-proBNP can be used as the determining indexes for evaluating severity degree of coronary artery disease,prognosis and curative effect.