| 微粉化对黄芩苷粉体学性质的影响 |
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| 引用本文： | 严红梅,丁冬梅,孙娥,汪晶,贾晓斌,张振海.微粉化对黄芩苷粉体学性质的影响[J].中国中药杂志,2014,39(4):653-656. |
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| 作者姓名： | 严红梅 丁冬梅 孙娥 汪晶 贾晓斌 张振海 |
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| 作者单位： | 江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;南京中医药大学, 江苏 南京 210046;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;南京中医药大学, 江苏 南京 210046;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028 |
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| 基金项目： | 国家“十一五”科技支撑计划项目（2008BAI51B03）；江苏省社会发展科技支撑计划项目（BE2010756）；江苏省中医药科技项目（LZ11065） |
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| 摘 要： | 该研究对黄芩苷进行微粉化处理，系统考察分析微粉化对黄芩苷粉体学性质的影响，采用扫描电镜法（SEM）、差示扫描量热法（DSC）和X-射线粉末衍射法（XRD）等方法分析比较黄芩苷普通粉和微粉的微观结构，测定粉体学参数，进行吸湿性研究，并考察微粉化对黄芩苷溶出度的影响。黄芩苷在微粉化之后化学成分没有改变，并且具有良好的可压性，改善溶出效果明显，微粉化技术在促进难溶性成分黄芩苷的吸收中具有一定的应用价值。
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| 关 键 词： | 黄芩苷 微粉化 粉体学性质 微观结构 溶出度 |
| 收稿时间： | 2013/8/19 0:00:00 |
Effects of micronization on micromeritics properties of baicalin |
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| YAN Hong-mei,DING Dong-mei,SUN E,WANG Jing,JIA Xiao-bin and ZHANG Zhen-hai.Effects of micronization on micromeritics properties of baicalin[J].China Journal of Chinese Materia Medica,2014,39(4):653-656. |
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| Authors: | YAN Hong-mei DING Dong-mei SUN E WANG Jing JIA Xiao-bin and ZHANG Zhen-hai |
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| Institution: | Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Nanjing University of Chinese Medicine, Nanjing 210046, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China;Nanjing University of Chinese Medicine, Nanjing 210046, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China |
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| Abstract: | Baicalin extremely fine powder was made by using ball-mill and the effect of micronization on the micromeritics properties of baicalin was studied and analyzed. The microstructures of baicalin ordinary and extremely fine powder were compared by scanning electron microscope, differential scanning calorimeter and X-ray diffraction and the powder characteristic of them was investigated. The hygroscopicity was studied. The effect of micronization on the dissolution of baicalin was investigated. The results showed that the chemical constituents of baicalin were not changed after micronization with better compressibility. It was confirmed that micronization technology had a certain application value in promoting the insoluble component of baicalin absorption with higher dissolution. |
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| Keywords: | baicalin micronization pharmaceutical properties microstructures dissolution |
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