| 黄芩苷对中波紫外线辐射后小鼠皮肤氧化应激及DNA损伤的影响 |
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| 引用本文： | 许阳,周炳荣,骆丹.黄芩苷对中波紫外线辐射后小鼠皮肤氧化应激及DNA损伤的影响[J].中国中西医结合皮肤性病学杂志,2011,10(6):343-345. |
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| 作者姓名： | 许阳 周炳荣 骆丹 |
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| 作者单位： | 南京医科大学第一附属医院,南京,210029 |
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| 摘 要： | 目的观察黄芩苷对中波紫外线(UVB)辐射后小鼠皮肤氧化应激及DNA损伤的影响。方法将黄芩苷外搽于Balb/c小鼠皮肤,检测180mJ/cm2UVB辐射后24h小鼠皮肤厚度及过氧化氢和CPDs产量。结果无论是UVB辐射前还是辐射后外用黄芩苷均明显减轻紫外线辐射造成的小鼠皮肤增厚。外用黄芩苷还可减少因UVB辐射诱导的小鼠皮肤组织中过氧化氢和CPDs产量。结论黄芩苷可抵抗UVB诱导的小鼠皮肤增厚,减少光产物表达,并通过减少活性氧簇的产生而发挥抗氧化作用。
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| 关 键 词： | 黄芩苷 中波紫外线 光损伤 |
Effects of Baicalin on UVB-mediated Oxidative Stress and DNA Damages in Mice Skins |
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| XU Yang,ZHOU Bing-rong,LUO Dan.Effects of Baicalin on UVB-mediated Oxidative Stress and DNA Damages in Mice Skins[J].Chinese J of Dermatovenerology Integr Tradit and West Med,2011,10(6):343-345. |
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| Authors: | XU Yang ZHOU Bing-rong LUO Dan |
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| Institution: | XU Yang,ZHOU Bing-rong,LUO Dan First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China |
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| Abstract: | Objective To observe the effects of baicalin on UVB-mediated damages in mice skins.Methods DNA damage models of UVB irradiation-induced mice epidermis were established.The skins' thickness was detected.Histochemical staining was used to detect hydrogen peroxide.The immunohistochemical staining was used for CPDs detection.Results Our data demonstrated that a topical application of baicalin,either pre-or post-UVB irradiation,resulted in a significant decreasing in UVB-mediated increases in skin thickness.Furt... |
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| Keywords: | baicalin ultraviolet B photodamage |
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