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| 乌梅丸对溃疡性结肠炎大鼠结肠组织白细胞介素8及13表达的影响 | |
| 引用本文： | 余欣,邱明义,刘建军,陶春晖.乌梅丸对溃疡性结肠炎大鼠结肠组织白细胞介素8及13表达的影响[J].中国中西医结合消化杂志,2011,19(3):172-174. |
| 作者姓名： | 余欣 邱明义 刘建军 陶春晖 |
| 作者单位： | 1. 武汉市第三医院,中医科,湖北,武汉,430061 2. 湖北中医学院,伤寒教研室,湖北,武汉,430060 3. 黄骅市人民医院,中医科,河北,黄骅,061100 |
| 摘 要： | 目的]探讨乌梅丸对大鼠溃疡性结肠炎（UC）结肠组织白细胞介素8（IL-8）及白细胞介素13（IL-13）表达的影响。方法]采用2,4-二硝基氯苯（DNCB）加醋酸复合法制备大鼠UC模型。动物随机分为正常对照组、模型组、柳氮磺胺吡啶（SASP）组和乌梅丸大、中、小剂量组6组。采用免疫组织化学染色法检测结肠组织IL-8、IL-13的表达。结果]与正常组相比,模型组大鼠结肠组织中IL-8的阳性表达显著增高（P〈0.01）,而乌梅丸各剂量组、SASP组则较模型组明显降低（P〈0.01）。与正常组相比,模型组大鼠结肠组织中IL-13的阳性表达显著降低（P〈0.01）,而乌梅丸各剂量组、SASP组则较模型组明显升高（P〈0.01）。结论]IL-8I、L-13参与了UC的发生。乌梅丸可能是通过下调IL-8,上调IL-13达到治疗UC的目的。 |
| 关 键 词： | 结肠炎 溃疡性 白细胞介素8 白细胞介素13 乌梅丸 |
Wumei pill regulates the expression of interleukin-8 and interleu-kin-13 in colon of rat with ulcerative colitis |
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| YU Xin,QIU Ming-yi,LIU Jian-jun,TAO Chun-hui.Wumei pill regulates the expression of interleukin-8 and interleu-kin-13 in colon of rat with ulcerative colitis[J].Chinese Journal of Integrated Traditional and Western Medicine on Digestion,2011,19(3):172-174. | |
| Authors: | YU Xin QIU Ming-yi LIU Jian-jun TAO Chun-hui |
| Institution: | YU Xin1,QIU Ming-yi2,LIU Jian-jun3,TAO Chun-hui2(1Department of Traditional Chinese Medicine,the Wuhan Third Hospital,Wuhan 430061,China,2Hubei University of Traditional Chinese Medicine,3Department of Traditional Chinese Medicine,Huanghua People'sHospital,Huanghua 061100,China) |
| Abstract: | Objective]To investigate the impact of Wumei pills on the expression of the interleukin-8 and interleukin-13 in the colon tissue of rats with ulcerative colitis(UC).Methods]2,4-Dinitrochlorobenzene(DNCB)plus acetate was used to prepare rat model of UC.Animals were randomly divided into six groups including control,DNCB group,salicylazosulfapyridine(SASP)group and Wumei pill high dose,medium dose and low dose group.The expression of interleukin-8 and interleukin-13 in the intestinal tissue were tested by i... |
| Keywords: | ulcerative colitis interleukin-8 interleukin-13 Wumei pill |
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