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肝硬化患者糖尿病与原发性肝癌相关性的研究
引用本文:张敏,金波,向轶,孟繁平,高银杰,马雪梅,郭晓东,李捍卫.肝硬化患者糖尿病与原发性肝癌相关性的研究[J].传染病信息,2009,22(2):98-100.
作者姓名:张敏  金波  向轶  孟繁平  高银杰  马雪梅  郭晓东  李捍卫
作者单位:解放军第三○二医院,北京,100039
摘    要:目的探讨肝硬化患者中糖尿病与原发性肝癌(primary hepatic carcinoma,PHC)发生的相关性。方法对2001年12月-2008年12月解放军第jo二医院诊断为肝炎肝硬化、酒精性肝硬化患者22132例(合并PHC患者6169例为病例组)进行病例对照研究,分析肝硬化患者中糖尿病与PHC的发生有无相关性,并按病因(包括乙型肝炎肝硬化、丙型肝炎肝硬化和酒精性肝硬化)分层分析其相关程度。结果在肝硬化患者中,合并糖尿病患者发生PHC的OR值为1.851(95%CI,1.693~2.023,X^2=184.55,P=0.000),其中乙型肝炎肝硬化、内型肝炎肝硬化和酒精性肝硬化组的OR值分别为1.850(95%CI,1.666~2.050,X2=137.52,P=0.000)、2.238(95%CI,1.738~2.882,X2=38.97,P=-0.000)和1.935(95%CI,1.472~2.567,X^2=20.89,P=0.006)。结论肝硬化患者合并糖尿病可以增加发牛PHC的胍险,在丙型肝炎肝硬化患者最为明显。

关 键 词:原发性肝癌  肝硬化  糖尿病  病例对照研究

Correlation between diabetes mellitus and primary hepatic carcinoma in patients with liver cirrhosis
Zhang Min,Jin Bo,Xiang Yi,et al..Correlation between diabetes mellitus and primary hepatic carcinoma in patients with liver cirrhosis[J].Infectious Disease Information,2009,22(2):98-100.
Authors:Zhang Min  Jin Bo  Xiang Yi  
Institution:Zhang Min,Jin Bo,Xiang Yi,et al.302 Hospital of PLA,Beijing 100039,China
Abstract:Objective To evaluate the correlation between diabetes mellitus and primary hepatic carcinoma(PHC) in patients with liver cirrhosis.Methods A case-control study was performed on 22 132 patients with post-hepatitis cirrhosis and alcoholic cirrhosis who were admitted in 302 hospital of PLA during Dec.2001 and Dec.2008.Among the patients,6 169 patients complicated by PHC were included in the case group,and the others in the control group.Analysis were performed to evaluate whether diabetes mellitus contributed...
Keywords:primary hepatic carcinoma  liver cirrhosis  diabetes mellitus  case-control study  
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