溃疡性结肠炎患者血浆P选择素水平及血小板计数的变化及其临床意义

目的探讨溃疡性结肠炎（UC）患者血浆P选择素（P—sel）水平及血小板计数的变化及其临床意义。方法采用酶联免疫分析方法检测45例UC患者和20例同期健康体检者血浆P—sel水平，采用血细胞记数仪测定血小板计数。结果随着病情的加重，UC患者血浆P-sel水平和血小板计数逐渐升高，差异有统计学意义（P〈0．01）。同时，UC活动期血浆P-sel水平[（31．9±6．9）μg/L]明显高于对照组[（15．6±4．8）μg/L]和uc缓解期[（22．1±5．5）μg/L]（P〈0．01）；UC缓解期明显高于对照组（P〈0．05）。UC活动期血小板计数[（230．8±75．9）×10^9／L]明显高于对照组[（163．1±47．8）×10^9／L]（P〈0．01），明显高于UC缓解期[（167．3±49．5）×10^9/L]（P〈0．01）；UC缓解期与对照组比较，差异无统计学意义（P〉0．05）。结论P—sel与UC的发病和病情进展密切相关，临床联合检测UC患者血浆P—sel水平及血小板计数，对病情的判断及其疗效的评估有一定参考价值。

Clinical significance and diversification of plasma P-selectin and platelet count in patients with ulcerative colitis

Objective To study the clinical significance and diversification of plasma P-selectin and plate-let count in patients with ulcerative colitis (UC). Methods The levels of plasma P-selectin were detected by enzyme-linked immunosorbnent assay; the platelet count was detected by blood cell counting instrument in patients with UC (n = 45) and healthy people recieving medical examination during the same period (n = 20). Results With the progress of UC, the plasma P-selectin and platelet count in patients with UC gradually increased (P <0.01, P < 0.05). The levels of plasma P-selectin in the active UC group were significandy higher than those in the control group (P <0.01), significantly higher than those in the remittent UC group(P <0.01). The platelet count in the active UC group were significantly higher than that in the control group (P < 0.01) and significantly higher than that in the remittent UC group (P<0.01). Conclusion P-selectin is closely related to the incidence of UC and the progress of disease. Combined detection of plasma P-selectin and platelet count in patients with UC has ref-erence value for the disease estimation and the efficacy assessment.