注射用甲磺酸培氟沙星与9种药物发生沉淀反应的原因分析

目的：分析甲磺酸培氟沙星在临床配伍时发生沉淀反应的原因,以指导临床合理用药。方法：通过查阅相关文献,选取有用的实验现象与数据进行分析,从而找出引起沉淀的各方面原因。结果：甲磺酸培氟沙星在临床使用主要与3种不同类型的药物产生沉淀或结晶。结论：甲磺酸培氟沙星粉针应使用葡萄糖注射液溶解并稀释,其溶液不能与碱性药物配伍或在同一输液管中连续滴注,避免与中成药针剂混合使用。

Analysis on the cause of the precipitation reaction between the Pefloxacin Mesylate for Injection and nine kinds of drugs

Objective：To guide clinical rational drug use by analyzing pefloxacin mesylate in clinical compatibility occurs when precipitation causes in order to guide the using in clinic. Methods：Through access to relevant literature,select a useful experimental results and data analysis in order to identify drug compatibility when the precipitation caused by various reasons. Results：Pefloxacin mesylate clinic used mainly three different types of drugs precipitation or crystallization. Conclusion：Pefloxacin mesylate powder for Injection should be used grapes sugar Injection dissolved and diluted,its solution can not be compatibility with the basic drugs or in the same continuous drip infusion tube,avoiding the use of proprietary Chinese medicines for Injection.