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| 连芪消渴胶囊对2型糖尿病大鼠肾损害的保护作用 | |
| 引用本文： | 温航远,杨新波,黄正明,陈红艳,陈劲春.连芪消渴胶囊对2型糖尿病大鼠肾损害的保护作用[J].解放军药学学报,2010,26(2):113-116. |
| 作者姓名： | 温航远 杨新波 黄正明 陈红艳 陈劲春 |
| 作者单位： | 1. 100029,北京,北京化工大学,生命科学与技术学院;100853,北京,解放军总医院,老年医学研究所临床药理室 2. 解放军总医院,老年医学研究所临床药理室,北京,100853 3. 解放军302医院药学部临床药理室,北京,100039 4. 北京化工大学,生命科学与技术学院,北京,100029 |
| 摘 要： | 目的研究连芪消渴胶囊对2型糖尿病大鼠肾损害的保护作用。方法采用高糖高脂饲料配合低剂量链脲佐菌素（30mg/kg）方法诱导2型糖尿病大鼠模型。将成模大鼠分为模型组、连芪消渴胶囊（2、4、8g/kg）治疗组、盐酸二甲双胍（0.2g/kg）组,治疗8周各组大鼠进行空腹血糖、肾功能相关指标检测以及肾脏组织学观察。结果与正常组对比,模型组空腹血糖、肾指数、尿量、微量白蛋白、血肌酐、尿素氮出现明显升高,超氧化物歧化酶水平降低而丙二醛水平升高,大鼠肾脏组织出现明显损伤变化;与模型组对比,连芪消渴胶囊（4、8g/kg）治疗组肾指数、尿量、微量白蛋白、血肌酐、尿素氮明显降低,肾组织超氧化物歧化酶水平升高和丙二醛水平降低;肾脏组织结构损伤变化得到改善。结论连芪消渴胶囊具有保护糖尿病肾功能损伤的作用,该作用与其降低空腹血糖及调节肾组织氧化应激水平有关。 |
| 关 键 词： | 连芪消渴胶囊 2型糖尿病大鼠 糖尿病肾病 |
A Study of Renoprotective Effect of Lianqi xiaoke Capsule in Type 2 Diabetic Rats |
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| WEN Hang-yuan,YANG Xin-bo,HUANG Zheng-ming,CHEN Hong-yan,CHEN Jin-chun.A Study of Renoprotective Effect of Lianqi xiaoke Capsule in Type 2 Diabetic Rats[J].Pharmaceutical Journal of Chinese People's Liberation Army,2010,26(2):113-116. | |
| Authors: | WEN Hang-yuan YANG Xin-bo HUANG Zheng-ming CHEN Hong-yan CHEN Jin-chun |
| Institution: | WEN Hang-yuan,YANG Xin-bo,HUANG Zheng-ming,CHEN Hong-yan,CHEN Jin-chunDepartment of Biology Science , Technology,Beijing University of Chemical Technology,Beijing 100029,China,Department of Clinical Pharmacology,Geriatric Institute of General Hospital of PLA,Beijing 100853,Department of Pharmacology of Pharmacy,Hospital 302 of PLA,Beijing 100039 |
| Abstract: | Objective To investigate the renoprotective effect of Lianqi xiaoke Capsule on type 2 diabetic rats. Methods A type 2 diabetic rats model was induced with high sucrose-fat diet and streptozotocin(STZ,30 mg/kg). Diabetic rats were randomly grouped into the model group, Lianqi xiaoke Capsule treatment groups(2, 4, 8 g/kg), and metforminhydrochloride tables group(0.2 g/kg). After 8 weks of administration, the level of fasting blood glucose, renal function indices and pathological changes were observed. Results... |
| Keywords: | Lianqi xiaoke Capsule type 2 diabetes rats diabetic nephropathy |
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