Efficiency of Refracterin in Patients with Chronic Cardiac Insufficiency Caused by Coronary Heart Disease |
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| Authors: | S. G. Kanorskii P. A. Galenko-Yaroshevskii K. B. Zingilevskii |
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| Affiliation: | M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow. |
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| Abstract: | Study of the expression of type IV collagen by Lewis pulmonary carcinoma cells (PLMG-T, PLMG-M1, PLMG-M2) showed that these cells produce type IV collagen. The expression of type IV collagen in PLMG-T and PLMG-M2 cells approximately 2-fold surpassed that in PLMG-M1 cells. The number of active cells (synthesizing type IV collagen) in PLMG-M1 culture was 1.6 and 2.2 times lower than in PLMG-M2 and PLMG-T cultures, respectively. It was found that cell culture medium modulated expression of type IV collagen and this effect was mediated via cell receptors. |
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| Keywords: | refracterin ischemic heart disease chronic cardiac insufficiency |
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