40848例医院患者和体检者乙型肝炎病毒表面抗原分布

目的了解本院患者和体检者乙型肝炎病毒（HBV）的感染情况并探讨其防范措施。方法采用时间分辨免疫荧光分析法,对2010-2012年来本院就诊的40 848例患者的血清标本进行乙型肝炎表面抗原（HBsAg）检测,并对其结果进行分析。结果 12010-2012年患者的HBsAg阳性率分别为9.3%（1 061/11 406）、9.79%（1 201/12 264）及8.36%（1 436/17 178）,合计9.05%（3 698/40 848）。不同年份间患者HBsAg阳性率的差异有统计学意义（χ2=19.047,P59岁将患者年龄分为低龄,中龄和高龄3组,不同年龄段患者HBsAg阳性率的差异有统计学意义（χ2=983.161,P〈0.05）;其中中龄组（20-59岁）HBV感染率最高。3不同性别患者间HBsAg阳性率的差异有统计学意义（χ2=168.075,P〈0.05）,以男性10.72%（2404/22422）高于女性。42010-2012年间,不同来源的患者包括门诊、住院、体检者HBsAg阳性率分别为14.26%（1 861/13 221）、7.05%（1 365/19 360）及5.71%（482/8 267）,差异有统计学意义（χ2=602.212,P〈0.05）。结论 2010-2012三年间本院患者HBsAg阳性率为9.05%,中龄组HBV感染率最高,男性高于女性,应加强乙肝防控宣传力度,接种乙肝疫苗可有效预防和控制乙肝流行。

Analysis of Results in Detection of HBsAg in 40 848 Cases

Objective To investigate the HBV infection situation among patients in our hospital,in order to provide theoretic basis for the prevention of HBV infection. Methods time-resolved fluoroimmunoassay （TRFIA） in our hospital HBsAg in serum in 40 848 cases of patients was detected by from 2010 to 2012. Results 1. The HBsAg positive rates of 2010,2011,2012 were 9.3%,9. 79% and 8. 36%respectively,and the total positive rate of this 3 years was 9. 050/oo. there were significant differences in HBsAg positive rates among the three year （x2= 19. 047 ,P〈0.05）. 2. Cases were divided in- to young-age group（〈20 years old）. Middle-age group（20-59）and aged group （〉59 years old）. Significant difference of HBsAg positive rates in the different age groups was found （x2= 983. 161,P〈0. 05）,The middle-age group showed the highest infection rate. 3. The positive rate in male was higher than that in female. There was a significant difference （x2 = 168. 075 ,P〈0. 05）. 4. The HBsAg positive rates of outpatients ,inpatient and normal individuals were14.26%, 7.05%and 5.71%. there was statistical significance（X2=602. 212,P〈0.05）. Conclusion The HBsAg positive rates of patients in our hospital from 2010 to 2012 was 9.05%. The middle-age group showed the highest infection rate. The positive rate in male was higher than that in female. The HBV infection rates showed the tendency of decrease from 2010 to 2012. Strengthen mass propaganda and education to prevent HBV. We suggest that no infection people inject vaccine HBV infection would be pretected and decreased.