| 铅门宽度和螺距在肺癌脑转移患者螺旋断层放疗计划设计中的研究 |
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| 引用本文： | 朱夫海,吴伟章,王勇,郭静,王颖杰,夏廷毅.铅门宽度和螺距在肺癌脑转移患者螺旋断层放疗计划设计中的研究[J].中国医疗器械杂志,2014(4):301-304. |
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| 作者姓名： | 朱夫海 吴伟章 王勇 郭静 王颖杰 夏廷毅 |
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| 作者单位： | 中国人民解放军空军总医院肿瘤放疗科,北京市100142 |
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| 基金项目： | 总后卫生部资助课题（08G048）,空军总医院年度临床攻关项目（Kzg2011001） |
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| 摘 要： | 对7例肺癌脑转移患者按照铅门宽度（1 cm，2.5 cm和5 cm）和螺距（0.15,0.30和0.45）的组合设计螺旋断层放疗计划，对其靶区、正常组织和治疗时间差异分析比较。所有计划均给予全脑CTV 30 Gy，转移灶GTV 50 Gy，计划分次为10次。结果证明靶区仅GTV的平均剂量和适形度（CI）差异有统计学意义（P =0.0021, P =0.0128），危及器官均在正常剂量限制范围以内，治疗时间与铅门宽度近似成反比例，螺距对其影响较小。研究表明5 cm的铅门宽度能够有效缩短治疗时间、提高治疗效率。
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| 关 键 词： | 螺旋断层放疗 铅门宽度 螺距 肺癌脑转移 |
Investigation of Field Width and Pitch in Tomotherapy Treatment Plans for Brain Metastases from Lung Cancer |
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| Zhu Fuhai,Wu Weizhang,Wang Yong,Guo Jing,Wang Yingjie,Xia Tingyi.Investigation of Field Width and Pitch in Tomotherapy Treatment Plans for Brain Metastases from Lung Cancer[J].Chinese Journal of Medical Instrumentation,2014(4):301-304. |
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| Authors: | Zhu Fuhai Wu Weizhang Wang Yong Guo Jing Wang Yingjie Xia Tingyi |
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| Institution: | (Department of Radiation Oncology, Air Force General Hospital, Beijing, 100142) |
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| Abstract: | Tomotherapy plans were produced using a combination offi eld widths （1 cm, 2.5 cm and 5 cm） and pitches （0.15, 0.30, and 0.45） for seven patients with brain metastases from lung cancer, the plans were compared with dosimetric parameters, protection of organs at risk （OAR） dose and treatment times. Al plans were defi ned that CTV with 30Gy and GTV 50 Gy by ten fraction synchronously. The results showed that the mean dose andCI for GTV was statistical difference （P=0.002 1,P=0.012 8）, OARs were within the normal range, the treatment time increased inversely proportional to the jaw width, but had lesser impact on the pitch.This study showed plans produced with 5 cm jaw was an effective method for patients with brain metastases from lung cancer. |
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| Keywords: | helical tomotherapy fi led width pitch brain metastases from lung cancer |
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