| Egr—1在小鼠和人体正常组织中的表达及其生理学功能 |
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| 引用本文： | 庄楚香,吴名耀. Egr—1在小鼠和人体正常组织中的表达及其生理学功能[J]. 汕头大学医学院学报, 2001, 14(3): 166-168 |
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| 作者姓名： | 庄楚香 吴名耀 |
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| 作者单位： | 1. 汕头大学医学院生理学教研室
2. 汕头大学医学院病理学教研室 |
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| 摘 要： | 目的：探讨早期生长反应基因-1（Egr-1)在小鼠和人体正常组织细胞中的表达情况及其生理学功能，方法：用原位杂交和免疫组织化学方法对小鼠和人的不同组织进行Egr-1检测。结果：Egr-1mRNA和Egr-1蛋白阳 性信号呈棕褐色，位于细胞浆和细胞核，组织中生长活跃的细胞可见相对高水平的Egr-1表达。结论：Egr-1mRNA和Egr-1蛋白的高表达主要在生长活跃的组织并有重要的生理学功能。
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| 关 键 词： | Egr－1 生理学功能 原位杂交 免疫组织化学 生长反应基因－1 |
| 文章编号： | 1007-4716-（2001）03-0166-03 |
| 修稿时间： | 2001-06-04 |
Egr-1 Expression in Normal Mouse and Human Tissues and Its Physiologic Function |
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| Zhuang Chuxiang. Egr-1 Expression in Normal Mouse and Human Tissues and Its Physiologic Function[J]. Journal of Shantou University Medical College, 2001, 14(3): 166-168 |
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| Authors: | Zhuang Chuxiang |
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| Abstract: | Objective: To study the expression of early growth response gene-1(Egr-1) in normal mouse and human tissues and its physiologic function. Methods: In-situ hybridization and immunohistochemistry were used respectively to detect Egr-1mRNA and protein in different tissues of mouse and human.Results:Egr-1 mRNA and Egr-1 protein positive signals were brown in color, located in cytoplasm and nucleus. Egr-1 expression had relatively high level in active growth cells. Conclusion: The expressions of Egr-1 mRNA and Egr-1 protein are mainly in active growth tissues and play an important physiologic function. |
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| Keywords: | Egr-1 Physiologic Function In-situ Hybridization Immunohistochemistry |
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