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Efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis in vitro and in an experimental model of actinomycetoma in BALB/c mice |
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| Authors: | Chacon-Moreno Brenda Edith Welsh Oliverio Cavazos-Rocha Norma de la Luz Salazar-Cavazos Maria Garza-Lozano Hector Gerardo Said-Fernandez Salvador Ocampo-Candiani Jorge Vera-Cabrera Lucio |
| Affiliation: | Servicio de Dermatología, Hospital Universitario José E. González, Monterrey, NL, Mexico. |
| Abstract: | The efficacy of ciprofloxacin and moxifloxacin against Nocardia brasiliensis was evaluated by applying 25 mg of each drug/kg subcutaneously every 8 h in BALB/c mice infected with N. brasiliensis. A statistically significant difference was observed only with moxifloxacin. A moxifloxacin-trimethoprim-sulfamethoxazole combination was as active as when each compound was used alone. |
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