| 胸腺瘤中P53蛋白表达研究 |
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| 引用本文： | 吴涛,倪灿荣.胸腺瘤中P53蛋白表达研究[J].中国临床神经科学,1999,7(4):201-203. |
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| 作者姓名： | 吴涛 倪灿荣 |
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| 作者单位： | 第二军医大学长海医院神经科 200433(吴涛，涂来慧，张仁琴)，第二军医大学长海医院病理科 200433(倪灿荣，詹榕洲) |
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| 摘 要： | 目的:研究P53蛋白在胸腺瘤中的表现及临床意义。方法:用免疫组化染色法观察54例胸腺瘤中P53蛋白表达阳性细胞密度和分布。结果:发现P53表达与胸腺瘤浸润与否密切相关,26例恶性胸腺瘤(Ⅰ和Ⅱ型)中18例P53蛋白高度表达,而28例非浸润性胸腺瘤仅2例高度表达(P＜0.01),P53高度表达患者生存期较非高度表达者明显短。显示P53蛋白表达异常可作为胸腺瘤病变性质和判断病人预后的指标。54例胸腺瘤中49例P53蛋白表达阳性(90.7%)。结论:P53表达异常发生于胸腺瘤的早期。
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| 关 键 词： | 胸腺瘤 P53蛋白 免疫组织化学 预后 |
Expression of P53 Protein in Thymomas |
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| Wu Tao,Tu Lai-Hui,Zhang Ren-Qin,Zhan Rong-Zhou,Ni Chan-Rong.Expression of P53 Protein in Thymomas[J].Chinese Journal of Clinical Neurosciences,1999,7(4):201-203. |
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| Authors: | Wu Tao Tu Lai-Hui Zhang Ren-Qin Zhan Rong-Zhou Ni Chan-Rong |
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| Institution: | Wu Tao,Tu Lai-Hui,Zhang Ren-Qin,Zhan Rong-Zhou,Ni Chan-Rong Departments of Neurology and Pathology,Changhai Hospital,Shanghai 200433 |
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| Abstract: | Aim: To study the expression of P53 in thymomas and its clinical values. Methods: The expression of P53 protein in 54 thymomas was examined immunohistochemically. Results: The expression of P53 correlated to the invasion of thymomas, 18 cases of 26 malignant thymomas were high expressors (the P53-positive tumor cells>50%), whereas only 2 cases of 28 noninvasive thymomas were high expressors. The survival rate was significantly higher for patients with P53 non-high expression than for those with P53 high expression. Conclusion: The expression of P33 protein was a good indicator for the prognosis of thymomas. The high rate of P53 expressions in thymomas (90. 7%)suggested that P53 may be implicated in initial stages of tumorigenesis. |
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| Keywords: | thymomu P53 immunohistochemistry prognosis |
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