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Effects of discriminant and non-discriminant dopamine antagonists on in vivo accumulation of 3H-N-propyl-norapomorphine in mouse striatum and tuberculum olfactorium |
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| Authors: | C. Gulat-Marnay A. Lafitte J. -C. Schwartz P. Protais |
| Affiliation: | (1) Laboratoire de Physiologie, Université René-Descartes, 4 Avenue de l'Observatoire, F-75005 Paris, France;(2) Unité de Neurobiologie de l'INSERM, U-109, 2 ter rue d'Alésia, F-75014 Paris, France;(3) Laboratoire de Pharmacodynamie et Physiologie, U.E.R. de Médecine et Pharmacie, F-76800 St.-Etienne-du-Rouvray, France |
| Abstract: | Summary The in vivo accumulation of 3H-N-propyl norapomorphine in mouse striatum and tuberculum olfactorium and its inhibition by a series of classical neuroleptics and discriminant benzamide derivatives previously identified in behavioural and radioligand experiments has been studied.The ID50 values in the two brain areas did not significantly differ with any studied compound. In addition the regional distribution of a discriminant compound related to sulpiride and administered in tritiated form to rats was rather homogeneous.These data do not indicate a preferential accumulation of these compounds in limbic as opposed to striatal areas. |
| Keywords: | Dopamine receptors 3H-N-propyl-norapomorphine Discriminant dopamine antagonists Striatum Tuberculum olfactorium |
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