山莨菪碱对体外循环心脏手术后白细胞变形力的影响

为观察山莨菪碱对体外循环（ＣＰＢ）心脏手术后病人白细胞变形能力（ＬＤ）的影响，进一步探讨该药改善微循环的机制。将１６例体外循环下心脏手术病人均分为实验、对照组。实验组于术后６０分钟静脉注射山莨菪碱０．２ｍｇ／ｋｇ。两组分别于术前、术后６０、给药后３０、６０分钟采外周血，测定白细胞变形力。结果显示，ＣＰＢ术后６０分钟两组白细胞变形力均明显降低（Ｐ＜０．０１），组间差异无显著性（Ｐ＞０．０５）。实验组给药后３０分钟ＬＤ高于对照组（Ｐ＜０．０１），但两组仍低于术前（Ｐ＜０．０１），给药后６０分钟实验组ＬＤ恢复至术前水平（Ｐ＞０．０５），明显高于对照组（Ｐ＜０．０１）。结论：ＣＰＢ术后ＬＤ降低，山莨菪碱对微循环的改善除作用于血管平滑肌及内皮外，提高ＬＤ亦起着重要作用

The Effect of Anisodamine on Leukocyte Deformability during Cardiopulmonary Bypass

Aim:This study was conducted to evaluate the effect of anisodamine on leukocyte deformability(LD)during cardiopulmonary bypass(CPB).Clinical material and method:Sixteem patients with congenital heart disease or rheumatic valve disease underwent open heart surgery under CPB.The patients were randomly divided into two groups.Control group(n=8)received no anisodamine after surgery.Treatment group(n=8)received 0.2mg/kg anisodamine intravenously 60 minutes after CPB.Blood samples were taken at four different time intervals for assessing LD.Result:LD was decreased significantly at 60 minute after CPB in both groups( P< 0.01),but there was no significant difference between two groups.At 30 minute after administration of anisodamine,LD was increased markedly in treatment group than that in control group(P<0.01).At 60-minute after giving anisodamine,LD returned to its basic level in treatment group but still staged low in control group.Conclusion:The elevation decreased LD is related to cardiopulmonary bypass.Postoperative treatment of anisodamine could improve myocardial microcirculation by means of enhance LD.