经皮瘤内注射联合肝动脉灌注热碘油治疗兔肝VX_2瘤

目的评价经皮穿刺瘤内注射联合肝动脉灌注60℃热碘油治疗兔VX2瘤的抑瘤效果。方法将VX2瘤细胞接种于24只新西兰白兔左肝内,随机分为3组,经皮穿刺瘤内注射联合肝动脉灌注60℃热碘油3 ml为联合组,经肝动脉灌注常温25℃碘油3 ml为常温组,经肝动脉灌注化疗药物为对照组。术后10 d计算瘤体坏死率,观察荷瘤兔的存活期及血清AST水平。结果联合组肿瘤的生长率(0.85±0.31)%与对照组(3.16±0.65)%和常温组(1.52±0.36)%相比有显著性差异(P<0.05)。联合组的存活期(48.3±3.0)d与常温组(39.2±2.5)d和对照组(31.5±3.5)d相比有显著性差异(P<0.05);术后10 d血清AST,联合组与常温组及对照组相比无显著性差异(P>0.05)。结论经皮穿刺瘤内注射联合肝动脉灌注60℃热碘油治疗兔VX2瘤较单纯肝动脉栓塞或化疗更有效,能降低肿瘤生长率,延长存活时间。

Effect of percutaneous intratumoral injection combined with hepatic artery perfused heated lipiodol on VX2 tumor in rabbits

Objective To assess the suppression tumor effect of percutaneous intratumoral injection and hepatic artery perfused heated lipiodol(60 ℃) in treatment of VX2 tumor in rabbits.Methods VX2 tumor cells were vaccinated into left liver of 24 New Zealand white rabbits,and which were divided into 3 groups randomly: combined group received percutaneous intratumoral injection of combinning hepatic artery perfused 3ml heated lipiodol(60 ℃),normal group was perfused 3ml normal lipiodol(25 ℃) through hepatic artery,and control group was perfused chemotherapic agents by hepatic artery;the necrosis rate of the tumor was calculated,meanwhile,the survival period and AST level of blood serum were observed 10 days after the operation.Results Compared with control group(3.16±0.65) and normal group(1.52±0.36),the tumorous growth rate of combined group had significant differences(P<0.05).And the survival period of combined group(48.3±3.0) was different obviously(P<0.05) from control group(39.2±2.5) and normal group(39.2±2.5).The AST level of blood serum of the 3 groups did not have marked differences(P>0.05) 10 days after the operation.Conclusion Effect of percutaneous intratumoral injection combined with hepatic artery perfused heated lipiodol(60 ℃) on VX2 tumor in rabbits is better than alone arterial embolism or chemotherapy,and could reduce the growth rate of tumor and prolong the survival time.