Protect effect of bicyclol on cisplatin-induced nephrotoxicity in mice |
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Authors: | Ying-Nan Yu Hui Chen Yan Li |
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Institution: | (1) Department of New Drug Development, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Xian Nong Tan Street, 100050 Beijing, People’s Republic of China |
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Abstract: | This study investigated the protective effects of bicyclol against cisplatin-induced nephrotoxicity and the possible mechanisms
in mice. Bicyclol (250 mg/kg, p.o., 5 days) showed significant protection as evidenced by the decrease of elevated serum creatine
and blood urea nitrogen, and improvement of histopathological injury induced by cisplatin. The formation of kidney malondialdehyde
with a concomitant reduction of reduced glutathione were also inhibited by bicyclol, while the activities of kidney superoxide
dismutase, catalase and glutathione peroxidase were all increased, respectively. Bicyclol also inhibited the increase of kidney
and serum nitric oxide induced by cisplatin. In addition, induction of induced nitric oxide synthase and nitrotyrosine were
suppressed by bicyclol. Bicyclol suppressed cisplatin-induced extracelluar signal regulated kinases 1/2 and p38 mitogen-activated
protein kinase activation in the kidney of mice. Results obtained demonstrate that bicyclol pre-administration can prevent
the nephrotoxicity induced by cisplatin. |
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Keywords: | Cisplatin Nephrotoxicity Bicyclol Oxidative stress Lipid peroxidation |
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