Plasma Neutrophil Gelatinase-Associated Lipocalin (NGAL) Correlations With Cystatin C, Serum Creatinine, and Glomerular Filtration Rate in Patients After Heart and Lung Transplantation |
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Authors: | M Szewczyk T Wielkoszyski M Zakliczyski M Zembala |
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Institution: | aSilesian Center for Heart Diseases, Zabrze, Poland;bDepartment of Chemistry, Medical University of Silesia, Zabrze, Poland |
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Abstract: | ObjectiveKidney injury represents a major clinical problem in orthotopic heart transplant (OHT) patients which seriously increases the mortality rate. The aim of this work was to evaluate the utility of a new kidney damage marker—neutrophil gelatinase-associated lipocalin (NGAL)—and its correlations with cystatin C, creatinine, and glomerular filtration rate (GFR) among patients after heart or lung transplantation.Materials and MethodsWe examined serum samples from 71 patients after heart transplantation, 7 patients after lung transplantation, and 20 healthy controls to measure serum NGAL using an enzyme-linked immunosorbent assay (ELISA) method; cystatin C using latex immunonephelometry; and creatinine using the alkaline-picrate method.ResultsSerum NGAL levels were significantly elevated among transplant patients, but did not significantly correlate with cystatin C in the transplant group (R = .13; P = .11) or in the control group (R = .26; P = .26), or GFR in the transplant group (R = −.09; P = .25) or in the control cohort (R = .22; P = .36). In the transplant group, serum NGAL positively correlated with serum creatinine (R = .27; P = .001).ConclusionsPlasma NGAL was not a specific biomarker for monitoring chronic renal disorders. We did not exclude other pathologies that might contribute to increased serum NGAL levels. |
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