检测阴道液中胎盘α微球蛋白-1诊断胎膜早破的价值

目的 探讨定性检测阴道液中胎盘α微球蛋白-1(PAMG-1)诊断胎膜早破的价值.方法 前瞻性对照分析100例有胎膜早破症状和体征患者的阴道液中PAMG-1和传统的诊断方法,并且回顾患者最初及所有后来的鉴定和临床过程后作评价.结果 检测PAMG-1诊断胎膜早破的灵敏度为100%(89/89),特异度为91%(10/11),阳性预测值为99%(89/90),阴性预测值为100%(10/10),假阳性率为9%(1/11),灵敏度和阴性预测值明显高于传统的诊断方法,差异有统计学意义(P<0.01).结论 检测阴道液PAMG-1对胎膜早破的诊断优于传统的诊断方法.

Placental alpha-microglobulin-1 in vagina liquid to diagnose premature rupture of membranes

Objective To explore the value of placental alpha-microglobulin-1 in vagina liquid to diagnose premature rupture of membranes. Methods A prospective observational study to initial evaluation included both the standard clinical evaluation for rupture of membranes and placental alpha-microglobulin-1 immunoassay. Rupture of membranes was diagnosed if fluid was seen leaking from the cervical os or if two of the following three conditions were present: pooling of fluid, positive nitrazine test, or feming. Rupture of membranes was diagnosed definitively on review of the medical records after delivery. Results Placental alpha-microglobulin-1 immunoassay confirmed rupture of membranes at initial presentation with a sensitivity of 100% (89/89), specificity of 91% (10/11), positive predictive value of 99% (89/90), and negative predictive value of 100% (10/10),false positive rate of 9% (1/11). Placental alpha-nricroglobulin-1 immunoassay was better than the conventional clinical assessment in confirming the diagnosis of rupture ofmembranes (P<0.01). Conclusion Measurement of placental alpha-microglobulin-1 in cervicovaginal secretions is superior to conventional clinical assessment in the diagnosis of rupture of membranes.