| PD-1/PD-Ls信号通路在肿瘤免疫逃逸及其治疗中的作用 |
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| 引用本文： | 王水英,孙宇,金惠.PD-1/PD-Ls信号通路在肿瘤免疫逃逸及其治疗中的作用[J].医学综述,2013,19(11):1973-1975. |
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| 作者姓名： | 王水英 孙宇 金惠 |
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| 作者单位： | 王水英 (上海中医药大学附属岳阳中西医结合医院,上海,200437);孙宇 (上海中医药大学附属岳阳中西医结合医院,上海,200437);金惠 (同济大学生命科学与技术学院细胞分子免疫学实验室,上海,200092); |
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| 基金项目： | 上海高校特聘教授"东方学者"资助项目(项目编号：2008-037)上海市人才发展基金(项目编号：2009-022) |
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| 摘 要： | 肿瘤免疫治疗已经成为肿瘤治疗的一个重要研究领域,免疫共刺激分子PD-1/PD-Ls作为负性免疫调节分子,在介导肿瘤细胞免疫逃逸中发挥着重要的作用。近年来,对于PD-1/PD-Ls与肿瘤免疫逃逸关系的研究已越来越深入,主要包括其分子功能、表达水平高低与肿瘤预后的关系等,尤其是对以PD-1/PD-Ls为靶点的临床肿瘤治疗研究取得了可喜的成果。该文就PD-1及其配体PD-Ls的发现、表达、功能以及在肿瘤免疫逃逸、肿瘤治疗中的作用等的研究进展予以综述,并对其应用前景进行展望。
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| 关 键 词： | 程序性死亡-1 程序性死亡配体1 程序性死亡配体2 肿瘤 |
Role of PD-1/PD-Ls Signal Pathway in Tumor Immunity Escape and Its Treatment |
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| WANG Shuiying,SUN Yu,JIN hui,CHENG Xiao-dong.Role of PD-1/PD-Ls Signal Pathway in Tumor Immunity Escape and Its Treatment[J].Medical Recapitulate,2013,19(11):1973-1975. |
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| Authors: | WANG Shuiying SUN Yu JIN hui CHENG Xiao-dong |
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| Institution: | 1,2. (1. Yueyang TCM & Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China; 2. Laboratory of Cellular and Molecular Immunology,School of Life Sciences and Technology,Tongji University,Shanghai 200092,China) |
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| Abstract: | Tumor immunotherapy has become an important field of research in cancer treatment.As a negative immune regulatory molecule,the immune stimulating molecules of PD-1 / PD-Ls play an important role in tumor cell-mediated immune escape.In recent years,the study of the relationship between PD-1 / PD-Ls and tumor immunity has become more deeper,including their molecular function,expression level correlation with tumor prognosis,especially in the research of cancer treatment by PD-1 / PD-Ls,gratifying achievements have been made.Here is to make a review of PD-1 and its ligand PD-Ls,including the discovery,expression,functions,as well as the relationship with tumor;and the PD-1 / PD-Ls application is also prospected. |
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| Keywords: | Programmed death-1 Ligand 1 of programmed death-1 Ligand 2 of programmed death-1 Tumor |
| 本文献已被 CNKI 等数据库收录！ |
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