消化性溃疡病患者治疗前后血清GM—CSF、IL-8和IL-6水平检测的临床意义

目的探讨了消化性溃疡病患者治疗前后血清GM—CSF、IL-8和IL-6水平的变化及意义。方法应用放射免疫法对36例消化性溃疡患者进行了血清GM—CSF、IL一8和IL-6水平测定，并与35名正常健康人作比较。结果消化性溃疡患者在治疗前血清GM—CSF、IC-8和IL-6水平非常显著地高于正常人组（P〈0．01），经中西医结合治疗3个月后则与正常人比较无显著性差异（P〈0．01），结论血清GM．CSF、IL-8和IL-6水平异常升高是消化性溃疡病发病的病理因素之一，有重要的临床价值。

Clinical significnce of measurement of changes of sercan GM-CSF、IL-8、IL-6 levels after-crentment in patients with peptic alcer

Objective To explore the changes of serclm GM-CSF、IL-8 and IL-6 levels both before and after treatment in paticents with peptic ulcer.Metheds Serccm GM-CSF IL-8 and IL-6 levels were measured with RIA in 36 patients with peptic celcer both Before and after treatment as well as in 35 controls.Results Before freatment,the serclun GM-CSF IL-8 and IC-6 levels were significantly higher in the patients than those in the contrels(P<0.01).after 3 months treatment.The levels were not significantly different from those in contrals(P>0.05).Conclusions Abnormal higher sercun GM-CSF.IL-8 and IL-6 levels played inuportant role in the pathogenesis of peptic ulcer.