洗必太在动物体内吸收的实验研究

<正> 洗必太(chlorhexidine)是一种性质稳定,毒性低的消毒剂。英国1959年收入药典,我国1977年载入药典,目前广泛应用于外科、妇科的消毒,并有加于牙膏内预防口腔感染者。我们与西南制药三厂协作,研制

EXPERIMENTAL STUDY ON ABSORPTION OF CHLORHEXIDINE IN ANIMALS

Chlorhexidine is originally in powder form which is poorly soluble in water. It became water soluble after the powder was dispersed and converted into drops form, and thus can be used for disinfection of drinking water and prevention of bacterial dysentery. The contents of the two forms of chlorhexidine in biological specimens were measured with liquid chromatography. It was indicated in experiment that chlorhexidine powder was slightly absorbed in animal body, while chlorhexidine drops was absorbed better. When a single dose of 200 mg/kg drops was given intragastrically to rabbits, the blood level of chlorhexidine rose to peak after 10 hr and was still measured to be 0.4 μg/ml 70 hr later. When a same single dose was given intragastrically to rats, the chlorhexidine content was found to be highest in liver, followed in decreasing order by kidney, heart, lung and brain after 48 hr. The drug remained in various tissues for about 4 days. It could still be recovered from intestine at a recovery rate of 40% after 144 hr and disappeared completely only after 192 hr. The amount of chlorhexidine excreted in urine reached a peak after 48 hr and disappeared after 120 hr.