开展内分泌代谢疾病及肾上腺肿瘤的表观遗传学研究

本文介绍了表观遗传学的定义和发展过程,及其在多种疾病(包括内分泌代谢病)发病机制中所起的重要作用.比较了遗传学和表观遗传学在解释肿瘤发病机制上的差别,并作了图解和说明.强调了环境因素通过表观遗传学的致病作用,提出了遗传和环境相互作用而致病的重要意义.指出在内分泌肿瘤(如嗜铬细胞瘤和神经母细胞瘤)应大力开展表观遗传学研究.

Abstract：

This editorial introduces the definition and development of epigenetics, and its theory in the pathogenesis of many diseases, including endocrine and metabolic diseases. The difference between genetics and epigenetics in explaining neoplastic pathogenesis is compared in detail with illustration. It emphasizes the importance of environmental factors as well as the interaction of genetical and environmental factors in causing the diseases. The article calls for more epigenetic research in endocrine neoplasm, especially in pheochromocytoma and neuroblastoma.

Carry out epigenetic research in endocrine and metabolic diseases and adrenal tumors

This editorial introduces the definition and development of epigenetics, and its theory in the pathogenesis of many diseases, including endocrine and metabolic diseases. The difference between genetics and epigenetics in explaining neoplastic pathogenesis is compared in detail with illustration. It emphasizes the importance of environmental factors as well as the interaction of genetical and environmental factors in causing the diseases. The article calls for more epigenetic research in endocrine neoplasm, especially in pheochromocytoma and neuroblastoma.