长期家庭氧疗对慢性阻塞性肺疾病患者生活质量影响的研究

目的探讨长期家庭氧疗对缓解期慢性阻塞性肺疾病（COPD）患者生活质量的影响。方法将我院老年病房确诊的34例COPD患者随机分为实验组（18例）、对照组（16例），两组均给予常规治疗，实验组缓解期在家庭内应用双鼻导管氧气筒吸氧，氧流量（1～2）L/min，每天吸氧时间为至少15h，总疗程均为12个月；定期随访患者吸氧的依从性。治疗前后两组均用St．George’s呼吸问卷（SGRQ）评估患者生活质量，测定血气分析、肺功能、6min步行距离（6MWD）。结果实验组1年后SGRQ评分明显低于治疗前及对照组（P〈0．05）；低氧血症、6MWD改善明显（P〈O．01）；肺功能变化不显著（P〉0．05）；而对照组FEVI％、FEVl／FVC％及PaCO2较实验前加重（P〈0．01）。治疗后两组间各项检测指标比较有显著性差异（P〈0．01）。结论长期家庭氧疗可明显改善缓解期COPD伴低氧血症患者的生命质量。

Research on the Effects of Home Long-term Oxygen Therapy on the Quality of Life in Patients with Chronic Obstructive Pulmonary Disease

Objective To disscuss the effects of Home Long-Term Oxygen Therapy（HLTOT）on the Quality of Life（QOL）in Patients with COPD in lysis period. Methods Thirty four cases from the elderly ward in our hospital were randomly divided into two groups： therapy group （n=lS）and control group （n=16）. The two groups were given the routine treatment. Additionaly, the therapy group re- ceived the oxygen therapy at home with nasal cannula. The oxygen flux is （1 -2）L/min. The whole time for oxygen therapy is 12 months for 15 hours a day at least. The obedience was regularly followed. The QOL is evaluated with St George＇s respiratory questionnaire （SGRQ）and artery blood gas analysis, pulmonary function and 6-Minute Walking Distance （6-MWD） were determined before and after treatment . Results The SGRQ scores were significantly lower than those before treatment and those in control group （P〈 0.05）in the therapy group after 1 year. And the levels of PaO2 and 6-MWD was significantly improved （P〈0.01）,but there was no difference in the level of pulmonary function （P〉0.05）,while the FE~1%,FEV1/FVC% and PaCO2 aggravated compared with before experiment in control group（P〈0.01）. There were significantly differences between the two groups in the level of each observed subject after the treatment. Conclusion HLTOT can prominently improve the QOL in Patients of COPD with Hypoxemia in lysis period.