氟西汀治疗卒中后抑郁150例的临床研究

目的观察氟西汀对脑卒中后抑郁症及神经功能恢复的疗效。方法将我院2006年1月～2010年1月收治的脑卒中后抑郁症患者300例随机分为治疗组及对照组各150例。两组均给予脑血管病常规治疗及相关的心理疏导，治疗组早餐后加服氟西汀20mg，连服8周，评测患者在治疗前、治疗后4周、治疗后6周、治疗后8周的HAMD评分。结果治疗组治疗后HAMD评分、抗抑郁疗效和神经功能恢复疗效明显高于对照组，经统计学比较有显著性差异（P〈0．05）。结论氟西汀对卒中后抑郁有良好效果，并能促进神经功能的恢复，值得临床上推广使用。

Effect of Fluoxetine on Post Stroke Depression:Clinical Investigation of 150 Cases

Objective To investigate the therapy effect of fluoxetine on 150 cases of post stroke depression （PSD）. Methods One hundred and fifty cases of PSD were randomly divided into two groups：treatment group and control group. The control group was only given the routine treatment of apoplexy and psychological counseling. The treatment group was given fluoxetine 20rag once a day besides routine treatment and psychological counseling. The treatment period of both groups was 8 weeks. The HAMD was evaluated before treatment and at weeks 4,6 and 8 after treatment. Results The HDRS,anti-depression effect and neurological recovery effect in the treatment group were much better than those in the control group,and there was a significant difference between the two groups （P〈0.05）. Conclusion Fluoxetine can obviously improve the symptoms and neurological function in PSD,worthy of being used in a wide range.