前额叶损伤患者情绪记忆的改变

目的 探讨前额叶损伤患者情绪记忆的损害情况,验证前额叶参与情绪记忆神经机制的假说.方法 建立情绪记忆的神经心理学测验方法,测试年龄、教育程度相匹配的40名健康人和40例前额叶损伤患者的情绪记忆情况.结果 与健康对照组正性(11.68±2.18)分和负性(12.93±1.33)分]相比,前额叶损伤组正性(8.20±2.02)分和负性(8.68±1.14)分]情绪效价图片再认成绩差异有统计学意义(t=7.41、-2.75,P＜0.05),而中性的情绪效价图片再认成绩差异无统计学意义.左、右侧前额叶损伤组的正性(8.90±2.01)分、(7.50±1.79)分]和负性(7.30±1.10)分、(9.05±1.00)分]情绪效价图片再认成绩差异均有统计学意义(Z=-2.15、-2.07,P＜0.05).结论 前额叶损伤患者的情绪记忆存在损害,且左、右侧前额叶损伤患者的正性与负性效价记忆相对存在不同差别的损害,表明其可能有不同的神经机制.

Abstract：

Objective To investigate the emotional memory impairment in patients with lesions located in prefrontal cortex(PFC), and to test the hypothesis that prefrontal cortex is involved in the emotional memory network. Methods The 40 patients with lesions in PFC and forty age-education-level matched healthy adults were given emotional memory tasks using positive, neutral and negative valence images. Results Compared with the healthy adults(positively(11.68 ± 2. 18)and negatively(12. 93 ±1.33)), the patients had significant loss in positively(8. 20 ± 2.02)and negatively(8. 68 ± 1.14)valence image memorizing(t = 7.41, - 2. 75, both P ＜ 0. 05). There was no insignificant impairment in neutral stimuli. Performance difference between left PFC and right PFC in positively(8. 90 ±2. 01 vs 7.50 ± 1.79)and negatively(7.30 ± 1.10 vs 9. 05 ± 1. 00)valence image recognition was significant(Z = -2. 15,-2. 07,both P ＜ 0. 05). Conclusion The results suggest that emotional memory is impaired in the patients with lesions in PFC. The impairment difference between left PFC and right PFC indicates that they may have different neuromechanisms.

Emotional memory impairment in patients with lesions in profronal cortex

Objective To investigate the emotional memory impairment in patients with lesions located in prefrontal cortex(PFC), and to test the hypothesis that prefrontal cortex is involved in the emotional memory network. Methods The 40 patients with lesions in PFC and forty age-education-level matched healthy adults were given emotional memory tasks using positive, neutral and negative valence images. Results Compared with the healthy adults(positively(11.68 ± 2. 18)and negatively(12. 93 ±1.33)), the patients had significant loss in positively(8. 20 ± 2.02)and negatively(8. 68 ± 1.14)valence image memorizing(t = 7.41, - 2. 75, both P ＜ 0. 05). There was no insignificant impairment in neutral stimuli. Performance difference between left PFC and right PFC in positively(8. 90 ±2. 01 vs 7.50 ± 1.79)and negatively(7.30 ± 1.10 vs 9. 05 ± 1. 00)valence image recognition was significant(Z = -2. 15,-2. 07,both P ＜ 0. 05). Conclusion The results suggest that emotional memory is impaired in the patients with lesions in PFC. The impairment difference between left PFC and right PFC indicates that they may have different neuromechanisms.