CALCIUM AND MAGNESIUM CONTENT OF SKELETAL MUSCLE: Studies in Subjects Undergoing Diagnostic Testing for Malignant Hyperthermia |
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| Authors: | NELSON T E; FLEWELLEN E H; BELT M W; KENNAMER D L; WINSETT O E; BEE D E |
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| Institution: | ¶Departments of Anesthesiology The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.
 Departments of Pharmacology and Toxicology The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.
 Departments of Surgery The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.
 Departments of Preventive Medicine community Health The University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.
Department of Anesthesiology Scott & White Clinic, Temple, Texas 76508, U.S.A. |
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| Abstract: | Ca2+ and Mg2+ contents were measured and compared among threedifferent malignant hyperthermia susceptible (MHS) diagnosticgroups. No difference was found among mean values for Ca2+ content,whereas Mg2+ content was greater in MHS muscle. Variance ofmeasured values was unequal and greatest among MHS muscles,suggesting a possible abnormal distribution associated withMHS. Although more muscle fibres with Ca2+  12 µmol g–1were observed in MHS muscle, this difference was not statisticallysignificant. In contrast, non-parametric analysis showed thatthe population of Mg2+ values was significantly greater in theMHS muscle. This study suggests that the distribution of Ca2+and Mg2+ values is different in MHS muscle as a result of unknowngenetic factors associated with the disease. |
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