| 小肠脂肪酸结合蛋白基因多态性与低出生体质量的关联研究 |
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| 引用本文： | 李宇,马海霞,程宁,何丽,白亚娜. 小肠脂肪酸结合蛋白基因多态性与低出生体质量的关联研究[J]. 临床荟萃, 2009, 24(10): 863-865 |
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| 作者姓名： | 李宇 马海霞 程宁 何丽 白亚娜 |
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| 作者单位： | 兰州大学,生殖健康与出生缺陷研究中心,甘肃,兰州,730000;兰州大学基础医学院,甘肃,兰州,730000;甘肃省妇幼保健院新生儿重症救护中心,甘肃,兰州,730050 |
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| 摘 要： | 目的研究小肠脂肪酸结合蛋白（IF ABP）基因exon Ⅱ54位点基因多态性与新生儿低出生体质量的关联。方法采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法,对86例低出生体质量儿和96例健康新生儿的IFABP基因多态性进行了检测,比较两组的基因型分布频率。结果IFABP基因型A54T频率分布为：AA、TT和AT基因型在疾病组中分别为24．4％、5．8％、69．8％,在对照组中分别为20．8％、41．7％、37．5％,分布频率差异有统计学意义（P=0．000）。T等位基因频率分别为40．7％和60．4％（P=0．000）。结论IFABP A54T基因多态性可能是低出生体质量儿的遗传易感因素;携带IFABP基因突变型54Ala／Thr的个体易患新生儿低体质量。
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| 关 键 词： | 婴儿 出生时低体重 基因频率 脂肪酸转运蛋白质类 聚合酶链反应 |
Relationship between polymorphism of human intestinal fatty acid binding protein gene and low birth mass in neonates |
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| LI Yu,MA Hai-xia,CHENG Ning,HE Li,BAI Ya-na. Relationship between polymorphism of human intestinal fatty acid binding protein gene and low birth mass in neonates[J]. Clinical Focus, 2009, 24(10): 863-865 |
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| Authors: | LI Yu MA Hai-xia CHENG Ning HE Li BAI Ya-na |
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| Affiliation: | LI Yu ,MA Hai-xia ,CHENG Ning , HE Li ,BAI Ya-na( 1. Center of Reproductive Health and Birth Defects ,Lanzhou University ,Lanzhou 730000 ,China 2. Neonatal Intensive Ambulance Centre ,Maternal and Child Health Care Hospital of Gansu Province, Lanzhou 730050, China ; 3. Institute of Epidemiology and Statistics ,Medical School ,Lanzhou University, Lanzhou 730000, China ; 4. Basic Medicine College, Lanzhou University, Lanzhou 730000, China) |
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| Abstract: | Objective To investigate whether genetic polymorphism in the intestinal fatty acid binding protein （IFABP） gene is associated with low birth mass in neonates. Methods Polymerase chain reaction-restriction fragment length polymorphism was used to detect the polymorphism in 86 low birth mass neonates and 96 normal ones. Results The A54T site frequencies of AA, TT, AT genotypes of IFABP gene were 24. 4 %, 5.8 %, 69.8 % in disease group while those were 20.8%, 41.7%, 37.5% in normal controls, the differences were significantly seen in the distribution frequency between two groups （ P = 0. 000）. Conclusion The combination between genetic polymorphisms in the IFABP gene in neonates is significantly associated with neonatal low birth mass;the frequency of encoding 54Ala/Thr polymorphism in IFABP gene is related with low birth mass. |
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| Keywords: | IFABP, polymorphisms infant, low birth weight gene frequency fatty acid transport proteins polymerase chain reaction |
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